Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.
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Angiogenin activates endothelial cell phospholipase CPurification of two distinct proteins of approximate Mr 80,000 from human epithelial cells and identification as proper substrates for protein kinase CA mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKSEffect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cellsStructural and functional aspects of platelet-derived growth factorProtein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.Cloning and molecular characterization of the murine macrophage "68-kDa" protein kinase C substrate and its regulation by bacterial lipopolysaccharideBrain protein kinase C phosphorylating poly(arginine,serine) or lamin B is stimulated by anions and by an activator purified from bovine serum albumin preparations.Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminalsFluorinated 4-quinolones induce hyperproduction of interleukin 2.Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C.Extracellular ATP induces the release of calcium from intracellular stores without the activation of protein kinase C in Swiss 3T6 mouse fibroblasts.Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.Embryonal carcinoma-derived growth factor activates protein kinase C in vivo and in vitro.Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes.Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.Differential expression of an 80-kDa protein kinase C substrate in preneoplastic and neoplastic mouse JB6 cells.Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase CThe 87-kDa protein, a major specific substrate for protein kinase C: purification from bovine brain and characterization.Protein kinase D1 mediates stimulation of DNA synthesis and proliferation in intestinal epithelial IEC-18 cells and in mouse intestinal crypts.Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxinPhosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein.Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.Synergistic regulation of human megakaryocyte developmentStimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activityWidespread occurrence of "87 kDa," a major specific substrate for protein kinase CProtein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells.Expression of the major protein kinase C substrate, the acidic 80-kilodalton myristoylated alanine-rich C kinase substrate, increases sharply when Swiss 3T3 cells move out of cycle and enter G0A tumor promoter induces rapid and coordinated reorganization of actin and vinculin in cultured cells.Effect upon mitogenic stimulation of calcium-dependent phosphorylation of cytoskeleton-associated 350,000- and 80,000-mol-wt polypeptides in quiescent 3Y1 cellsProtein kinase C activators suppress stimulation of capillary endothelial cell growth by angiogenic endothelial mitogens.Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia.Neuropeptides as cellular growth factors: role of multiple signalling pathways.Abnormal protein kinase C down regulation and reduced substrate levels in non-phorbol ester-responsive 3T3-TNR9 cells.Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C.Phorbol ester-induced actin cytoskeletal reorganization requires a heavy metal ion.
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P2860
Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@en
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@nl
type
label
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@en
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@nl
prefLabel
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@en
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@nl
P2093
P2860
P356
P1476
Phorbol esters, phospholipase ...... in intact quiescent 3T3 cells.
@en
P2093
Rodriguez-Pena M
Rozengurt E
P2860
P304
P356
10.1073/PNAS.80.23.7244
P407
P577
1983-12-01T00:00:00Z