Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. - Wikidata - awgldk - TriplyDB

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

http://www.wikidata.org/entity/Q37484749

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Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism Evolutionary determinants of cancer p53 Down regulates PDGF-induced formation of circular dorsal ruffles in rat aortic smooth muscle cells TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants Comparative genetics of longevity and cancer: insights from long-lived rodents Evolution under environmental stress at macro- and microscales Divergent evolution of human p53 binding sites: cell cycle versus apoptosis Evolutionary regulation of the blind subterranean mole rat, Spalax, revealed by genome-wide gene expression.Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer Lipid profile and serum characteristics of the blind subterranean mole rat, Spalax.Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patterns Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesis.Structure and stability insights into tumour suppressor p53 evolutionary related proteins.Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.An extracellular region of the erythropoietin receptor of the subterranean blind mole rat Spalax enhances receptor maturation.p53 gene discriminates two ecologically divergent sister species of pine voles Functional evolution of the p53 regulatory network through its target response elements.Long-lived cancer-resistant rodents as new model species for cancer research.Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, Spalax Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson.Molecular structure of heparan sulfate from Spalax. Implications of heparanase and hypoxia.Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasis Cellular adaptation to hypoxia and p53 transcription regulation.Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau.Molecular signatures of longevity: Insights from cross-species comparative studies.Gene expression signatures of human cell and tissue longevity.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell death p53 in mitochondria enhances the accuracy of DNA synthesis.p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.Migration-selection balance drives genetic differentiation in genes associated with high-altitude function in the speckled teal (Anas flavirostris) in the Andes.Exceptional Chromosomal Evolution and Cryptic Speciation of Blind Mole Rats Nannospalax leucodon (Spalacinae, Rodentia) from South-Eastern Europe.Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species.Macroscopic anatomy of the lower respiratory system in mole rats (Spalax leucodon).Combination of 247 genome-wide association studies reveals high cancer risk as a result of evolutionary adaptation.Genome Stability Maintenance in Naked Mole-Rat.Regarding Mole Rats and Cancer.

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Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

http://www.wikidata.org/entity/Q37484749

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 August 2004

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

@en

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

@nl

type

label

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

@en

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

@nl

prefLabel

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

@en

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

@nl

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PNAS.0404998101

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Proceedings of the National Academy of Sciences of the United States of America

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Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.

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Aaron Avivi

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Alma Joel

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Gadi Kajakaro

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Gideon Rechavi

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Konstantin Adamsky

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Luba Trakhtenbrot

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Meytal Cohen

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Ninette Amariglio

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