Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
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Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanismEvolutionary determinants of cancerp53 Down regulates PDGF-induced formation of circular dorsal ruffles in rat aortic smooth muscle cellsTP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephantsComparative genetics of longevity and cancer: insights from long-lived rodentsEvolution under environmental stress at macro- and microscalesDivergent evolution of human p53 binding sites: cell cycle versus apoptosisEvolutionary regulation of the blind subterranean mole rat, Spalax, revealed by genome-wide gene expression.Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancerLipid profile and serum characteristics of the blind subterranean mole rat, Spalax.Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patternsAdaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat SpalaxThe Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesis.Structure and stability insights into tumour suppressor p53 evolutionary related proteins.Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.An extracellular region of the erythropoietin receptor of the subterranean blind mole rat Spalax enhances receptor maturation.p53 gene discriminates two ecologically divergent sister species of pine volesFunctional evolution of the p53 regulatory network through its target response elements.Long-lived cancer-resistant rodents as new model species for cancer research.Adaptive methylation regulation of p53 pathway in sympatric speciation of blind mole rats, SpalaxChanging the p53 master regulatory network: ELEMENTary, my dear Mr Watson.Molecular structure of heparan sulfate from Spalax. Implications of heparanase and hypoxia.Alternatively spliced Spalax heparanase inhibits extracellular matrix degradation, tumor growth, and metastasisCellular adaptation to hypoxia and p53 transcription regulation.Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau.Molecular signatures of longevity: Insights from cross-species comparative studies.Gene expression signatures of human cell and tissue longevity.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell deathp53 in mitochondria enhances the accuracy of DNA synthesis.p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon.Migration-selection balance drives genetic differentiation in genes associated with high-altitude function in the speckled teal (Anas flavirostris) in the Andes.Exceptional Chromosomal Evolution and Cryptic Speciation of Blind Mole Rats Nannospalax leucodon (Spalacinae, Rodentia) from South-Eastern Europe.Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species.Macroscopic anatomy of the lower respiratory system in mole rats (Spalax leucodon).Combination of 247 genome-wide association studies reveals high cancer risk as a result of evolutionary adaptation.Genome Stability Maintenance in Naked Mole-Rat.Regarding Mole Rats and Cancer.
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Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 August 2004
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@en
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@nl
type
label
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@en
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@nl
prefLabel
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@en
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@nl
P2093
P2860
P356
P1476
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation.
@en
P2093
Aaron Avivi
Gadi Kajakaro
Gideon Rechavi
Konstantin Adamsky
Luba Trakhtenbrot
Meytal Cohen
Ninette Amariglio
P2860
P304
12236-12241
P356
10.1073/PNAS.0404998101
P407
P577
2004-08-09T00:00:00Z