The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease.
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Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.Differences in abundances of cell-signalling proteins in blood reveal novel biomarkers for early detection of clinical Alzheimer's diseaseA small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.Adenosine inhibits glutamatergic input to basal forebrain cholinergic neuronsGenetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease.Immunization Against Specific Fragments of Neurotrophin p75 Receptor Protects Forebrain Cholinergic Neurons in the Olfactory Bulbectomized MiceNeurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons.Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegenerationDiminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging.Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF.Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis.Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases.Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress.Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway.G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity.Cholinergic neurons-keeping check on amyloid β in the cerebral cortex.Amyloid-Beta Peptide, Oxidative Stress and Inflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Omega-3 Polyunsaturated Fatty Acids.Up-regulation of sortilin mediated by amyloid-β and p75(NTR): safety lies in the middle course.
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The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The role of the p75 neurotroph ...... nction in Alzheimer's disease.
@en
The role of the p75 neurotroph ...... nction in Alzheimer's disease.
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type
label
The role of the p75 neurotroph ...... nction in Alzheimer's disease.
@en
The role of the p75 neurotroph ...... nction in Alzheimer's disease.
@nl
prefLabel
The role of the p75 neurotroph ...... nction in Alzheimer's disease.
@en
The role of the p75 neurotroph ...... nction in Alzheimer's disease.
@nl
P2093
P2860
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The role of the p75 neurotroph ...... nction in Alzheimer's disease.
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P2093
P2860
P304
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10.1177/1073858408331376
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2009-05-20T00:00:00Z