Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking.
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Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its traffickingGephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding siteDiffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticityRegulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor 2 subunitTrak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic miceNeuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype.Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sortingDelivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neuronsInteraction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neuronsPrecursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processingMolecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrinPhospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmissionHuntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neuronsHuntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in miceThe residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor α1 subunit to gephyrinAHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders.Slow intracellular accumulation of GABA(A) receptor delta subunit is modulated by brain-derived neurotrophic factorPIP2 signaling in lipid domains: a critical re-evaluation.Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsyGABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.Studies on the Q175 Knock-in Model of Huntington's Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory DysfunctionHuntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestineEndosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE).Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligaseSelective expression of Huntingtin-associated protein 1 in {beta}-cells of the rat pancreatic islets.Adenosine-to-inosine RNA editing affects trafficking of the gamma-aminobutyric acid type A (GABA(A)) receptorHuntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice.Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticusPhosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions.Long distance effect on ligand-gated ion channels extracellular domain may affect interactions with the intracellular machinery.Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3.Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition.Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex.Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcriptionGlucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease miceGABAA receptor trafficking-mediated plasticity of inhibitory synapses.Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.
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P2860
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 August 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Huntingtin-associated protein ...... receptor membrane trafficking.
@en
Huntingtin-associated protein ...... receptor membrane trafficking.
@nl
type
label
Huntingtin-associated protein ...... receptor membrane trafficking.
@en
Huntingtin-associated protein ...... receptor membrane trafficking.
@nl
altLabel
Huntingtin-associated protein ...... receptor membrane trafficking
@en
prefLabel
Huntingtin-associated protein ...... receptor membrane trafficking.
@en
Huntingtin-associated protein ...... receptor membrane trafficking.
@nl
P2093
P2860
P356
P1476
Huntingtin-associated protein ...... receptor membrane trafficking.
@en
P2093
Philip Thomas
Stephen J Moss
Trevor G Smart
Verena Tretter
Yuri D Bogdanov
P2860
P304
12736-12741
P356
10.1073/PNAS.0401860101
P407
P577
2004-08-13T00:00:00Z