The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Adaptive evolution of voltage-gated sodium channels: the first 800 million yearsPhotoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin eggTPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channelsIntracellular calcium channels in protozoaReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscleThe ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.Ancestral Ca2+ signaling machinery in early animal and fungal evolution.TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADPA functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat.Two-pore channels for integrative Ca signaling.TRP channels of intracellular membranesCalcium channels in the development, maturation, and function of spermatozoa.NAADP receptors.Increased expression of fatty-acid and calcium metabolism genes in failing human heart.Two-Pore Channels: Lessons from Mutant Mouse ModelsAbsence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide.Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes.NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.Cyclic ADP-Ribose and NAADP in Vascular Regulation and Diseases.Regulation of acinar cell function in the pancreas.Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.Physiological roles of NAADP-mediated Ca2+ signaling.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.Calcium regulation in the protozoan model, Paramecium tetraurelia.Calcium-permeable ion channels in control of autophagy and cancerNeuronal calcium signaling: function and dysfunction.Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clampTPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.Voltage-gated calcium channels: Novel targets for cancer therapy.Deviant lysosomal Ca2+ signalling in neurodegeneration. An introduction.An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids.Ancient origin of four-domain voltage-gated Na+ channels predates the divergence of animals and fungi.Two distinct calcium pools in the endoplasmic reticulum of HEK-293T cells.
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P2860
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 28 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The acid test: the discovery o ...... somal Ca(2+) release channels.
@en
The acid test: the discovery of two-pore channels
@nl
type
label
The acid test: the discovery o ...... somal Ca(2+) release channels.
@en
The acid test: the discovery of two-pore channels
@nl
prefLabel
The acid test: the discovery o ...... somal Ca(2+) release channels.
@en
The acid test: the discovery of two-pore channels
@nl
P2093
P2860
P1433
P1476
The acid test: the discovery o ...... somal Ca(2+) release channels.
@en
P2093
A Mark Evans
Jianjie Ma
John Parrington
Michael X Zhu
Xiaotong Cheng
P2860
P2888
P304
P356
10.1007/S00424-009-0682-Y
P577
2009-05-28T00:00:00Z