TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+ - Wikidata - awgldk - TriplyDB

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

http://www.wikidata.org/entity/Q24621022

about

Two-pore channels form homo- and heterodimers Hax-1 identified as a two-pore channel (TPC)-binding protein Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells The role of TRPMLs in endolysosomal trafficking and function Two-pore channels function in calcium regulation in sea star oocytes and embryos.Regulation of lysosomal ion homeostasis by channels and transporters Two-pore channels at the intersection of endolysosomal membrane traffic Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient mice Domain assembly of NAADP-gated two-pore channels Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1 Linking NAADP to ion channel activity: a unifying hypothesis Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals Two-pore channels (TPCs): current controversies Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer NAADP receptors.Lysosomal physiology.VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.Function and dysfunction of two-pore channels.Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.Organelle-specific subunit interactions of the vertebrate two-pore channel family.Bilayer measurement of endoplasmic reticulum Ca2+ channels.Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels TRPML: transporters of metals in lysosomes essential for cell survival?Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes Reactivation of Lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells Regulation of TRPML1 function.

P2860

Q24337485-7B306B35-65A4-43C1-B7B0-FBA1EF93D585 Q24339389-0B006681-FC5D-4AD3-9BC4-79F52C91C23B Q24600390-E7565ECC-EE08-437C-965E-D4D7F4453CBA Q24600457-8A159418-98D0-4A19-AD57-B5D84A023484 Q26864223-8C55D8F9-91D3-48CB-BA94-D6117AC01BBC Q27346606-E87DDB97-D652-4964-A279-ECB12D41373A Q28069327-CAB70A31-8472-4812-8871-F0A5D7166B83 Q28085768-E05837C4-10F5-42D7-9B3A-659A9B5745A5 Q28240502-1A3309B9-4F45-4FF6-9CFF-3C779277965D Q28246421-71A75AA4-ABD1-48D6-B7B6-0F2C1E044D5C Q28250269-8934F1D5-695B-488E-8F56-12C7C357DE33 Q28260464-84DB7DAD-F557-4B6E-AC47-CA70EFAD03E4 Q28262391-295AB580-58D8-45F4-ADA8-50ABA9580057 Q28264441-97FECC79-8FFC-4B23-A231-662FE6C1A7AE Q28265293-6AAE8693-15A3-4E3C-A422-BCEF6BE9AB45 Q28274013-9917B0CD-D338-4743-A9B0-35A4B1B7398F Q28276964-72364091-1206-42DF-BD72-428A67018BC0 Q28286984-69B60551-3233-45C2-BFE0-A15EAB442E3B Q28294394-791CC3A8-31BA-4506-9CF5-DA651FDF2E8F Q28302766-437DF34E-2170-4836-9EB7-9757B016A3DE Q28307378-5CA9F23B-AA36-4398-8BD2-21E1D422FC0C Q30537868-6B4EB0AB-FEC9-415B-9158-E9D173C2C8B9 Q30835214-441C301C-05C8-43FE-BF22-FBD2DFA9D16A Q33771011-5753D0DF-493E-43C9-AF0C-CE9BBB885579 Q34147867-C000A129-A6D4-4D6A-94F8-46304A31F449 Q34462083-BE97D28F-75D9-4E62-B66C-80070D0A543B Q34480730-D754261A-7545-4C5B-860B-D1902C07B3EE Q34483905-135A3362-653B-4BD0-8C6F-4B17342C7454 Q34483914-6630520D-E5A6-43B1-9BA3-D7F7F19982DB Q34552502-793B3CDB-FF27-4B6D-9564-E922B14CD055 Q34583526-6BB9F038-9BA5-4771-B569-543A43673DCE Q34685254-5400304F-83AD-437B-AE43-B5596E7E4A5C Q34776238-D5B0B185-0D07-413C-A6E0-81DB7D57D310 Q34958437-ED7E61BE-43DC-4671-8ECC-6390E0F1D311 Q35049794-FDDB50AC-B229-4273-82CB-DEAD91C0A553 Q35067713-7E5C9195-D23B-4048-B097-27A412C51E52 Q35190170-B53DDC1D-B5E0-4248-8AC3-74F2EDBA7F1D Q35358079-2AB3C086-A3B1-45CB-B4A7-6AF0178A9FC1 Q35547893-22196939-8F03-4931-917D-1BA5CB3F9008 Q35640908-611E9745-A8F6-47EC-839B-8273342526B3

P2860

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

http://www.wikidata.org/entity/Q24621022

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@ast

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@en

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@nl

type

label

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@ast

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@en

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@nl

prefLabel

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@ast

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@en

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@nl

P1433

Q24621022-E4EAB8A1-1DD5-4ED6-8894-3C76DABB3379

P1476

Q24621022-EAE05BBD-D667-48B9-935B-C7DCB999AA99

P2093

Q24621022-06F929B6-711D-4204-9009-92CD550F172F

Q24621022-075C7CE2-DF17-45CB-8ED9-2CEDB93F3472

Q24621022-624CE313-D5C0-4A1A-9F22-9F3A545602C6

Q24621022-65EDC202-8F4B-4B98-9378-FF80F65444AE

Q24621022-6818F79E-5F9F-4164-8953-1655FD90C5D1

Q24621022-7B72103C-4A87-4691-9B56-22050FF0DE5A

Q24621022-9A25521C-E85D-4CAD-9D0D-1F8250209004

Q24621022-9B611659-E84E-4A22-AAA4-61A13E22FE4F

Q24621022-EF0A70BE-B6F2-43AC-B680-8E0A8BC4F2A1

P2860

Q24621022-00C8EC7A-6969-40C8-AFF2-7D45F1FE9765

Q24621022-1485B608-AC26-428F-BCE5-B05F6C5E35E4

Q24621022-1536AF78-30D8-4CE5-96DF-FF7F88282330

Q24621022-176707F7-0077-4B2F-994A-9CFF8C1FCE6F

Q24621022-19A2B3BF-8CE7-400B-947A-1D61C9CFFE76

Q24621022-1E202282-33CA-4CD2-A82F-4E052968E41B

Q24621022-2240E574-68A1-4669-AB95-6913227C9A67

Q24621022-250B554F-C14F-4AA7-ABD4-3E3CED66AF49

Q24621022-27226864-745E-4D94-9B46-36F8E03B9A8A

Q24621022-2DE0ED40-6E75-45C6-91C5-9EFE5BD388FD

P304

Q24621022-93685677-FCA4-4AE6-86EB-20471A79651F

P31

Q24621022-B8423D7C-BDC4-4889-A721-568153D9B78C

P3181

Q24621022-D9437836-2194-404E-92A4-BE8074AF2A0C

P356

Q24621022-762312D1-485E-48FA-AFEC-A1B65C99527F

P407

Q24621022-34F50784-A383-47C3-8DC9-19AAB555E271

P433

Q24621022-39C96525-7F33-40CD-9AFD-AD9A3575036E

P478

Q24621022-B3B3C9CD-12DF-4FB4-BEEB-E07081EA6AD4

P50

Q24621022-61DC9EF2-7722-4D60-9B02-E33AD3E6738D

Q24621022-757471E5-8A65-4F01-8AB5-1B83E4C69820

Q24621022-A8305AEF-30A5-455D-8EFB-AE4C5E58B6BD

Q24621022-AAAC28EC-A6A7-4AA1-A7A5-E32DB92F4FFB

P577

Q24621022-649FBB37-12A7-4161-898F-19792B75F69F

P698

Q24621022-7E6269B4-DBEF-41B4-9ABA-02CADC5B212E

P921

Q24621022-34C69AE9-8E06-4572-887C-94AEBBC38BE0

P932

Q24621022-ED902A2E-4B6D-4DC4-9100-77E1ED3E3DF6

P3181

P356

JBC.M110.156927

P1433

Journal of Biological Chemistry

P1476

TPC2 is a novel NAADP-sensitiv ...... sensor of luminal pH and Ca2+

@en

P2093

Grant C Churchill

http://www.w3.org/2001/XMLSchema#string

John Parrington

http://www.w3.org/2001/XMLSchema#string

Katja Rietdorf

http://www.w3.org/2001/XMLSchema#string

Mano Sitsapesan

http://www.w3.org/2001/XMLSchema#string

Margarida Ruas

http://www.w3.org/2001/XMLSchema#string

Michael X Zhu

http://www.w3.org/2001/XMLSchema#string

Rajendra Gosain

http://www.w3.org/2001/XMLSchema#string

Rebecca Sitsapesan

http://www.w3.org/2001/XMLSchema#string

Tim M Funnell

http://www.w3.org/2001/XMLSchema#string

P2860

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

NAADP mobilizes calcium from acidic organelles through two-pore channels

Identification of a chemical probe for NAADP by virtual screening

Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells

Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients

Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

Unique inactivation properties of NAADP-sensitive Ca2+ release

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose

P304

35039-46

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1226049

http://www.w3.org/2001/XMLSchema#string

P356

10.1074/JBC.M110.156927

http://www.w3.org/2001/XMLSchema#string

P407

P433

45

http://www.w3.org/2001/XMLSchema#string

P478

285

http://www.w3.org/2001/XMLSchema#string

P50

Antony Giuseppe Galione

P577

2010-11-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20720007

http://www.w3.org/2001/XMLSchema#string

P921

P932

2966118

http://www.w3.org/2001/XMLSchema#string