LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. - Wikidata - awgldk - TriplyDB

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

http://www.wikidata.org/entity/Q37499781

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Misregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasion LMO2 induces T-cell leukemia with epigenetic deregulation of CD4 SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes.Small genomic insertions form enhancers that misregulate oncogenes Developmental gene networks: a triathlon on the course to T cell identity.Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias.DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma.

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LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

http://www.wikidata.org/entity/Q37499781

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 January 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

@en

LIM domain only-2

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type

label

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

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LIM domain only-2

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prefLabel

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

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LIM domain only-2

@nl

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JOURNAL.PONE.0085883

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LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.

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Charnise Goodings

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Deborah A Swing

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Elizabeth Mathias

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J Andrew Hardaway

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James Downing

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Lino Tessarollo

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Liqi Li

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Mary Ann Thompson

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Natalina Elliott

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Paul Love

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P2860

The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival

Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors

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e85883

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scholarly article

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10.1371/JOURNAL.PONE.0085883

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1

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9

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Charles G. Mullighan

Neal G. Copeland

Nancy A. Jenkins

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2014-01-21T00:00:00Z

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259919881

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24465765

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3897537

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