The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells
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The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cellsCK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA bindingThe PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressorsMisregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasionHEX expression and localization in normal mammary gland and breast carcinomaPRH/Hhex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling.An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH.Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphomaNKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2aPRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.Multilayered specification of the T-cell lineage fate.NKL homeobox genes in leukemia.LIM-domain-only proteins in cancer.PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response.Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma.PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin.The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons.RUNX1 cooperates with FLT3-ITD to induce leukemia.Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a.Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia.Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice
P2860
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P2860
The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells
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2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The homeobox gene Hex induces ...... hematopoietic precursor cells
@ast
The homeobox gene Hex induces ...... hematopoietic precursor cells
@en
The homeobox gene Hex induces ...... hematopoietic precursor cells
@nl
type
label
The homeobox gene Hex induces ...... hematopoietic precursor cells
@ast
The homeobox gene Hex induces ...... hematopoietic precursor cells
@en
The homeobox gene Hex induces ...... hematopoietic precursor cells
@nl
prefLabel
The homeobox gene Hex induces ...... hematopoietic precursor cells
@ast
The homeobox gene Hex induces ...... hematopoietic precursor cells
@en
The homeobox gene Hex induces ...... hematopoietic precursor cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
The homeobox gene Hex induces ...... hematopoietic precursor cells
@en
P2093
Alex George
Herbert C Morse
Monica J Justice
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1206822
P407
P577
2003-10-02T00:00:00Z
P6179
1038843479