Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.

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Q37507447

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Fibroblasts, an inconspicuous but essential player in colon cancer development and progression Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition Cytokine-Induced Modulation of Colorectal Cancer Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth Immune cell interplay in colorectal cancer prognosis Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment Cytokines, IBD, and colitis-associated cancer IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway Microenvironmental regulation of therapeutic response in cancer Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3.Concise review: The obesity cancer paradigm: exploration of the interactions and crosstalk with adipose stem cells.Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells.Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis.Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism Immunity, inflammation, and cancer: an eternal fight between good and evil.Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF.Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma.IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin.Significance of Interleukin-6 in Papillary Thyroid Carcinoma.Cancer-associated fibroblasts promote endometrial cancer growth via activation of interleukin-6/STAT-3/c-Myc pathway.Prognostic role of serum concentrations of high-sensitivity C-reactive protein in patients with metastatic colorectal cancer: results from the ITACa trial Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta.Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells.Genetic alterations and epigenetic alterations of cancer-associated fibroblasts.Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways.Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer.Update on implications and mechanisms of angiogenesis in liver fibrosis.Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts.Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer.Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma.Emerging cytokine networks in colorectal cancer.Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.The chemokine receptor CXCR7 is a critical regulator for the tumorigenesis and development of papillary thyroid carcinoma by inducing angiogenesis in vitro and in vivo.

P2860

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P2860

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction.

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http://www.wikidata.org/entity/Q37507447

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article científic

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bilimsel makale

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scientific article published on 17 December 2013

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