The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.
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Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interactionPurified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinityRegulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene familyAlanine scanning of a putative receptor binding surface of insulin-like growth factor-ICrystal structure of the first three domains of the type-1 insulin-like growth factor receptorThe three dimensional structure of the type I insulin-like growth factor receptor.Cloning and characterisation of Schistosoma japonicum insulin receptorsThe role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesisSystematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analoguesEngineering of insulin receptor isoform-selective insulin analoguesA comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.The regulation of reproductive neuroendocrine function by insulin and insulin-like growth factor-1 (IGF-1).Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer : future possibilities for personalised treatment by use of biomarkers.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationThe first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cellsThe role of receptor tyrosine kinase inhibition in treating gastrointestinal malignancy.Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling.Interspecies molecular chimeras of kit help define the binding site of the stem cell factor.Regulation of muscle mass by growth hormone and IGF-I.A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.Replacements of leucine 87 in human insulin receptor alter affinity for insulin.The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction.Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.Theoretical and computational studies of peptides and receptors of the insulin family.Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells.Insulin-like growth factor receptors. Implications for nervous system function.Molecular defects of insulin/IGF-1 receptor transmembrane signaling.Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding.Structure and function of the insulin-like growth factor I receptor.Solution structure of a mini IGF-1A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptorDecoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site.Diversification of the insulin receptor family in the helminth parasite Schistosoma mansoni.Positive selection has driven the evolution of the Drosophila insulin-like receptor (InR) at different timescales.Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice.Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors
P2860
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P2860
The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1991
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
@da
vědecký článek
@cs
name
The ligand specificities of th ...... ions of a common binding site.
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The ligand specificities of th ...... ions of a common binding site.
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type
label
The ligand specificities of th ...... ions of a common binding site.
@en
The ligand specificities of th ...... ions of a common binding site.
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prefLabel
The ligand specificities of th ...... ions of a common binding site.
@en
The ligand specificities of th ...... ions of a common binding site.
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P2093
P2860
P356
P1476
The ligand specificities of th ...... ions of a common binding site.
@en
P2093
Andersen AS
Balschmidt P
Kjeldsen T
Rasmussen JS
Schäffer L
P2860
P304
P356
10.1073/PNAS.88.10.4404
P407
P577
1991-05-01T00:00:00Z