HtrA serine proteases as potential therapeutic targets in cancer.
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Substrate-induced remodeling of the active site regulates human HTRA1 activityMolecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell EnvelopeNewly folded substrates inside the molecular cage of the HtrA chaperone DegQProtoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine proteaseStructural and Functional Analysis of Human HtrA3 Protease and Its SubdomainsHtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.Inhibition of cell proliferation, migration and apoptosis in blue-light illuminated human retinal pigment epithelium cells by down-regulation of HtrA1.The autolysis of human HtrA1 is governed by the redox state of its N-terminal domainHtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathwaysRisk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes.HtrA1: Its future potential as a novel biomarker for cancer.Epigenetic silencing of serine protease HTRA1 drives polyploidy.Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants.The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferationGeneration and characterization of mice with a conditional null allele of the HtrA4 gene.HtrA1 expression associated with the occurrence and development of esophageal cancer.Temperature-induced changes of HtrA2(Omi) protease activity and structureHtrA3 Is Downregulated in Cancer Cell Lines and Significantly Reduced in Primary Serous and Granulosa Cell Ovarian Tumors.WAP four-disulfide core domain protein 2 gene(WFDC2) is a target of estrogen in ovarian cancer cellsNma111p, the pro-apoptotic HtrA-like nuclear serine protease in Saccharomyces cerevisiae: a short survey.Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response.Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets.Function and clinical relevance of kallikrein-related peptidases and other serine proteases in gynecological cancers.Antitumor activity and expression profiles of genes induced by sulforaphane in human melanoma cells.Inhibition of cell proliferation and migration after HTRA1 knockdown in retinal pigment epithelial cells.Allosteric regulation of DegS protease subunits through a shared energy landscape.Overexpression of HTRA1 leads to down-regulation of fibronectin and functional changes in RF/6A cells and HUVECs.HtrA3 is negatively correlated with lymph node metastasis in invasive ductal breast cancer.Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cellsHigh temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell linesIdentification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder.Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.Determinants of amyloid fibril degradation by the PDZ protease HTRA1.Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.A conserved activation cluster is required for allosteric communication in HtrA-family proteases.High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling.
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HtrA serine proteases as potential therapeutic targets in cancer.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
HtrA serine proteases as potential therapeutic targets in cancer.
@en
HtrA serine proteases as potential therapeutic targets in cancer.
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type
label
HtrA serine proteases as potential therapeutic targets in cancer.
@en
HtrA serine proteases as potential therapeutic targets in cancer.
@nl
prefLabel
HtrA serine proteases as potential therapeutic targets in cancer.
@en
HtrA serine proteases as potential therapeutic targets in cancer.
@nl
P2860
P1476
HtrA serine proteases as potential therapeutic targets in cancer.
@en
P2093
Mara Campioni
Viji Shridhar
P2860
P304
P356
10.2174/156800909788486704
P577
2009-06-01T00:00:00Z