Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
about
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer diseaseImpact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI miceAlpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissueRoles of tau protein in health and disease.The autolysis of human HtrA1 is governed by the redox state of its N-terminal domainCerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signalingSerine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid depositsEpigenetic silencing of serine protease HTRA1 drives polyploidy.Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticlesAge-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.Engineering therapeutic protein disaggregases.Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation.Designer protein disaggregases to counter neurodegenerative disease.Spatial regulation of coalesced protein assemblies: Lessons from yeast to diseases.HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective.Determinants of amyloid fibril degradation by the PDZ protease HTRA1.HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression.Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells.The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis.Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers.Amyloid assembly and disassembly
P2860
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P2860
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Human high temperature require ...... grades tau protein aggregates.
@en
Human high temperature requirement serine protease A1
@nl
type
label
Human high temperature require ...... grades tau protein aggregates.
@en
Human high temperature requirement serine protease A1
@nl
prefLabel
Human high temperature require ...... grades tau protein aggregates.
@en
Human high temperature requirement serine protease A1
@nl
P2093
P2860
P50
P356
P1476
Human high temperature require ...... grades tau protein aggregates.
@en
P2093
Anca Laura Tirniceriu
Anke Brockmann
Hanna Ksiezak-Reding
Leif Dehmelt
Linda Truebestein
Markus Kaiser
Michael Ehrmann
Nina Schmidt
Patrick Hauske
P2860
P304
20931-20941
P356
10.1074/JBC.M111.316232
P407
P577
2012-04-25T00:00:00Z