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Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1Disaggregases, molecular chaperones that resolubilize protein aggregatesPotential roles for prions and protein-only inheritance in cancerDistinct prion strains are defined by amyloid core structure and chaperone binding site dynamics.Substrate Discrimination by ClpB and Hsp104.Hsp104 overexpression cures Saccharomyces cerevisiae [PSI+] by causing dissolution of the prion seeds[PSI+] maintenance is dependent on the composition, not primary sequence, of the oligopeptide repeat domain.Low activity of select Hsp104 mutants is sufficient to propagate unstable prion variantsHsp40s specify functions of Hsp104 and Hsp90 protein chaperone machines.Does the central dogma still stand?Heterologous gln/asn-rich proteins impede the propagation of yeast prions by altering chaperone availabilityRecovery of small infectious PrP(res) aggregates from prion-infected cultured cells.Destabilization and recovery of a yeast prion after mild heat shock.Molecular chaperone Hsp104 can promote yeast prion generationPrion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.Heterologous aggregates promote de novo prion appearance via more than one mechanism.Molecular and functional characterization of the only known hemiascomycete ortholog of the carboxyl terminus of Hsc70-interacting protein CHIP in the yeast Yarrowia lipolytica.Prions in yeast.Haploid yeast cells undergo a reversible phenotypic switch associated with chromosome II copy numberNon-targeted identification of prions and amyloid-forming proteins from yeast and mammalian cells.The story of stolen chaperones: how overexpression of Q/N proteins cures yeast prions.Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates.Analysis of [SWI+ ] formation and propagation events.Prion-like proteins and their computational identification in proteomes.SUP35 expression is enhanced in yeast containing [ISP+], a prion form of the transcriptional regulator Sfp1.Exploring prion protein biology in flies: genetics and beyond.Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae.Regulation of chaperone effects on a yeast prion by cochaperone Sgt2.The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.Heterogeneous interaction network of yeast prions and remodeling factors detected in live cells.The small heat shock protein Hsp31 cooperates with Hsp104 to modulate Sup35 prion aggregation.Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation.Epigenetic inheritance, prions and evolution.Hsp104 as a key modulator of prion-mediated oxidative stress in Saccharomyces cerevisiae.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Hsp104 and prion propagation.
@en
Hsp104 and prion propagation.
@nl
type
label
Hsp104 and prion propagation.
@en
Hsp104 and prion propagation.
@nl
prefLabel
Hsp104 and prion propagation.
@en
Hsp104 and prion propagation.
@nl
P2860
P1476
Hsp104 and prion propagation.
@en
P2093
Nina V Romanova
Yury O Chernoff
P2860
P304
P356
10.2174/092986609788490078
P577
2009-01-01T00:00:00Z