Targeting mitochondrial apoptosis by betulinic acid in human cancers.
about
Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric CancerNatural compounds as anticancer agents: Experimental evidenceSynergistic combination of gemcitabine and dietary molecule induces apoptosis in pancreatic cancer cells and down regulates PKM2 expressionBetulinic acid in complex with a gamma-cyclodextrin derivative decreases proliferation and in vivo tumor development of non-metastatic and metastatic B164A5 cells.NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.Co-administration of betulinic acid and methamphetamine causes toxicity to dopaminergic and serotonergic nerve terminals in the striatum of late adolescent ratsBetulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitroInhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin.Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activityA potent tumoricidal co-drug 'Bet-CA'--an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cellsApproaches to improve the oral bioavailability and effects of novel anticancer drugs berberine and betulinic acid.Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acidSimultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulinBetulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.Molecular interaction studies of amorphous solid dispersions of the antimelanoma agent betulinic acidCombining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesisPI3K target based novel cyano derivative of betulinic acid induces its signalling inhibition by down-regulation of pGSK3β and cyclin D1 and potentially checks cancer cell proliferation.Structural elucidation of chemical constituents from Benincasa hispida seeds and Carissa congesta roots by gas chromatography: Mass spectroscopyParallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoidsSubcellular localization and activity of gambogic acidBetulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells.Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.Crude and purified proteasome activity assays are affected by type of microplate.Enzymatic biotransformation of terpenes as bioactive agents.Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target.Activators of AMPK: not just for type II diabetes.Adipocyte-derived players in hematologic tumors: useful novel targets?Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy.New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents.Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation.Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage.Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells.
P2860
Q26744362-E23EF34E-EA54-4209-860A-1C8E3D4FBC04Q26823107-6B40510C-680C-4E0B-9D4D-FB3F8497C2E5Q28542871-FA8C697F-8414-4DCE-AD43-560DEC73B7D1Q33755743-5976846D-4A95-47F5-AF7A-22A02896C0BBQ34013972-FBE2A4E8-F816-458B-A870-3B5A7B6712DBQ34428204-07376843-1E5E-4044-8522-F09103D13B26Q34445108-EC28DB97-F7E2-4065-B056-8E6C57FC17BBQ34541519-F11307D8-8AA4-4C7B-8C5E-39072900F272Q34592766-8723AECE-3693-446A-AB9B-76548AC6561AQ34948354-F144940B-684D-4882-949F-CC0CF01F3992Q35116352-4926AFE5-043E-4948-A05A-7AF19FB0FACDQ35152103-3B9AD6DF-44F5-4126-9B88-2805FCED6E83Q35165322-23CA39A8-9661-46FF-BCD7-5864B98A80D9Q35207278-E5F03DF4-F440-4C77-879C-77C9306C5C42Q35209956-EC7B01A9-4ECC-4269-B03E-DB950A913410Q35632714-F389A353-66D6-47CA-99D7-8E6C4DFA4D5EQ35642615-84902EF2-2BB1-4405-A663-6A9F440E76E7Q35679403-F1EC735C-6224-4476-B982-F2C5B946F172Q35890780-9F5C4E0F-77C7-4DE3-AF19-768E92F4C237Q35984980-03364D24-9FCE-47C0-88D9-BD9C8175F1DCQ36161820-C17550A9-1E08-4680-91ED-3F7ABB7CB068Q36216596-C7F0D7EA-9987-491A-BD79-ADCFAC30B667Q36494764-48E04662-9429-4817-BB82-2FD70D64D45CQ37046302-43DB6A16-54E8-4F45-934D-314E8AA236DCQ37513313-F8DE3260-DD2B-4BA6-884A-DDAA59A3F094Q38050531-75C54F2F-BC20-4A43-875D-98DCA139F2C0Q38209122-397E8DC9-580A-48F5-BEB0-A9F71EB57F0EQ38243893-E4811B63-F488-4407-B32A-ED3FDDDCA25EQ38259527-A0F1DF8F-AC0B-4E30-B4A3-D49AB72AE274Q38331755-4D25C0CA-A8C2-474D-A0D1-C74ACC106B85Q38624961-2FC24D37-9150-4376-B58C-66CFF803D6D3Q38854022-0BD010CE-5F97-426C-9B4E-4A60288EE0C7Q38888042-203EBB12-035B-442D-9173-4061C43FDD51Q38988403-AE9DC58E-2964-4CB5-BCE2-2EEE95C5E2F3Q39335751-9C33A6D2-112C-46AA-9429-1E46B2D938D2Q39394956-F9FC0AD2-1356-4978-B7A7-CF225E07D24CQ39478541-1BCB5C1C-1127-4239-B94A-EB8FE19A0995Q41845149-DF6A53CF-88DE-4A23-B56B-8B72C32B81D9Q46414472-359E3C1F-47C0-4D40-A3E2-5857BBB4AB61Q47343974-CEB96F5C-C67A-4FFD-BF76-280D15C46A79
P2860
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@en
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@nl
type
label
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@en
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@nl
prefLabel
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@en
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@nl
P1433
P1476
Targeting mitochondrial apoptosis by betulinic acid in human cancers.
@en
P304
P356
10.1016/J.DRUDIS.2009.05.015
P577
2009-06-09T00:00:00Z