Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.
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The autophagy-lysosomal system in subarachnoid haemorrhageThe endolysosomal system in cell death and survivalAMDE-1 is a dual function chemical for autophagy activation and inhibitionBetulinic acid and its derivatives: a patent review (2008-2013).Synthesis of antitumor-active betulinic acid-derived hydroxypropargylamines by copper-catalyzend mannich reactions.The nuclear receptor NR4A1 induces a form of cell death dependent on autophagy in mammalian cellsThe anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa.Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma.Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acidSimultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulinElaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cellsLithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo.Parallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoidsCeramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells.A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancyPerfluorooctane Sulfonate Induces Autophagy-Dependent Apoptosis through Spinster 1-Mediated lysosomal-Mitochondrial Axis and Impaired Mitophagy.Current questions and possible controversies in autophagy.Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline.Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.Novel pharmacological modulators of autophagy and therapeutic prospects.Integration of autophagy and anoikis resistance in solid tumors.Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy.Betulinic Acid and its Derivatives as Potential Antitumor Agents.Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis.Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease.Inhibition of Autophagy by Chloroquine Enhances the Antitumor Efficacy of Sorafenib in Glioblastoma.NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathwaysBetulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization.Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response.Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis.Pan-mammalian target of rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 proteinMultifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation.BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways.Rapid screening of potential autophagic inductor agents using mammalian cell lines.Natural Compounds As Modulators of Non-apoptotic Cell Death in Cancer Cells.Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells.
P2860
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P2860
Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Impairment of lysosomal integr ...... gy into a detrimental process.
@en
Impairment of lysosomal integr ...... gy into a detrimental process.
@nl
type
label
Impairment of lysosomal integr ...... gy into a detrimental process.
@en
Impairment of lysosomal integr ...... gy into a detrimental process.
@nl
prefLabel
Impairment of lysosomal integr ...... gy into a detrimental process.
@en
Impairment of lysosomal integr ...... gy into a detrimental process.
@nl
P2093
P2860
P356
P1476
Impairment of lysosomal integr ...... agy into a detrimental process
@en
P2093
A Tchoghandjian
P Gonzalez
S Cristofanon
S Enzenmüller
P2860
P2888
P304
P356
10.1038/CDD.2012.10
P577
2012-02-17T00:00:00Z