CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
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Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and TransactivityTherapeutic targeting of replicative immortalityCyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system.CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formationRepression of hypoxia-inducible factor α signaling by Set7-mediated methylation.Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.Regulation of cell proliferation by hypoxia-inducible factorsCyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma.Cell cycle progression in response to oxygen levels.The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β.Antileukemic effects of midostaurin in acute myeloid leukemia - the possible importance of multikinase inhibition in leukemic as well as nonleukemic stromal cells.A compendium of proteins that interact with HIF-1α.Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors.ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins.Phosphorylated ribosomal protein S6 correlation with p21 expression and inverse association with tumor size in oral squamous cell carcinoma.The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.Targeting CDK4/6 to oppose hypoxia-mediated therapeutic resistance.Overexpression of CBX3 in Pancreatic Adenocarcinoma Promotes Cell Cycle Transition-Associated Tumor Progression.The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression
P2860
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P2860
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
@en
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
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CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
@en
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
@nl
prefLabel
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
@en
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
@nl
P2093
P2860
P356
P1433
P1476
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth.
@en
P2093
David T Dicker
Jozef Malysz
Nathan G Dolloff
P2860
P304
P356
10.4161/CC.26930
P577
2013-10-25T00:00:00Z