Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis.
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A look at autoimmunity and inflammation in the eyeAn immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanismsTransplantation Tolerance Induction: Cell Therapies and Their MechanismsCell therapy to induce allograft tolerance: time to switch to plan B?Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A miceB-cell delivered gene therapy for tolerance induction: role of autoantigen-specific B cells.Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se.Inhibitors - cellular aspects and novel approaches for tolerance.Haemophilia A: effects of inhibitory antibodies on factor VIII functional interactions and approaches to prevent their action.Gene therapeutic approaches to induction and maintenance of tolerance.Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-β dependent regulatory T cells.Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity.B-Cell Gene Therapy for Tolerance Induction: Host but Not Donor B-Cell Derived IL-10 is Necessary for Tolerance.B cells "transduced" with TAT-fusion proteins can induce tolerance and protect mice from diabetes and EAEIL-22-induced regulatory CD11b+ APCs suppress experimental autoimmune uveitis.Gene therapy in systemic lupus erythematosus.Induction of tolerance to self-antigens using genetically modified bone marrow cells.Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis.B cells induce tolerance by presenting endogenous peptide-IgG on MHC class II molecules via an IFN-gamma-inducible lysosomal thiol reductase-dependent pathwayAntigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis.Activated B cells in autoimmune diseases: the case for a regulatory role.Peripheral induction of tolerance by retinal antigen expressionHydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells.Advances in the field of lentivector-based transduction of T and B lymphocytes for gene therapy.Gene therapy for noninfectious uveitis.In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance.High Efficiency Ex Vivo Gene Transfer to Primary Murine B Cells Using Plasmid or Viral VectorsTargeting MOG expression to dendritic cells delays onset of experimental autoimmune disease.Gene therapy in the treatment of autoimmune diseases.Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins.B-cell-delivered gene therapy induces functional T regulatory cells and leads to a loss of antigen-specific effector cells.Understanding autoimmune uveitis through animal models. The Friedenwald Lecture.Lymphopenia-induced proliferation is a potent activator for CD4+ T cell-mediated autoimmune disease in the retina.CD8+ regulatory T cells are responsible for GAD-IgG gene-transferred tolerance induction in NOD mice.Transduced B cells: B is for 'beneficial'!Non-myeloablative transplantation of bone marrow expressing self-antigen establishes peripheral tolerance and completely prevents autoimmunity in mice.From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance.Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta?Peripheral expression of rod photoreceptor arrestin induces an epitope-specific, protective response against experimental autoimmune uveoretinitis.
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Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2000
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@en
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@nl
type
label
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@en
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@nl
prefLabel
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@en
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@nl
P2093
P2860
P356
P1476
Retroviral gene therapy with a ...... perimental autoimmune uveitis.
@en
P2093
P2860
P304
P356
10.1172/JCI9168
P407
P577
2000-07-01T00:00:00Z