Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
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Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination.Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones.Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides.Insights into electron leakage in the reaction cycle of cytochrome P450 BM3 revealed by kinetic modeling and mutagenesis.Catalyst-Controlled Site-Selective Bond Activation.Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites.Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst.A dual substrate kinetic model for cytochrome P450BM3-F87G catalysis: simultaneous binding of long chain aldehydes and 4-fluorophenol.Furan-Site Bromination and Transformations of Fraxinellone as Insecticidal Agents Against Mythimna separata Walker.Micelle Delivery of Parthenolide to Acute Myeloid Leukemia Cells.
P2860
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P2860
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Discovery of potent parthenoli ...... ediated C-H functionalization.
@en
Discovery of potent parthenoli ...... ediated C-H functionalization.
@nl
type
label
Discovery of potent parthenoli ...... ediated C-H functionalization.
@en
Discovery of potent parthenoli ...... ediated C-H functionalization.
@nl
prefLabel
Discovery of potent parthenoli ...... ediated C-H functionalization.
@en
Discovery of potent parthenoli ...... ediated C-H functionalization.
@nl
P2093
P2860
P356
P1433
P1476
Discovery of potent parthenoli ...... ediated C-H functionalization.
@en
P2093
Craig T Jordan
Joshua N Kolev
Kristen M O'Dwyer
P2860
P304
P356
10.1021/CB400626W
P50
P577
2013-11-08T00:00:00Z