Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
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MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityThe base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrityMSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylationMutS homologue hMSH5: role in cisplatin-induced DNA damage responseThe FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cellsDNA polymerase delta is required for human mismatch repair in vitroATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsInteraction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatinMethylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2DNA mismatch repair: molecular mechanism, cancer, and ageingSeparation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutantMutS inhibits RecA-mediated strand transfer with methylated DNA substrates.The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancerProtein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove AdductsTumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsInteractions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAXStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesBcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activityAffinity of mismatch-binding protein MutS for heteroduplexes containing different mismatchesExpression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamideSeparation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genesDHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repairATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairSteady-state kinetic analysis of DNA polymerase single-nucleotide incorporation productsRole of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.Order of assembly of human DNA repair excision nuclease.The role of the Fanconi anemia network in the response to DNA replication stress.Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repairImproved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-linksConstruction and characterization of mismatch-containing circular DNA molecules competent for assessment of nick-directed human mismatch repair in vitro.Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylationNuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions.Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1
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P2860
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@en
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@nl
type
label
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@en
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@nl
prefLabel
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@en
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@nl
P2093
P2860
P356
P1476
Human MutSalpha recognizes dam ...... r the cisplatin-d(GpG) adduct.
@en
P2093
A I Murchie
D M Lilley
D R Duckett
J T Drummond
J T Reardon
P2860
P304
P356
10.1073/PNAS.93.13.6443
P407
P577
1996-06-01T00:00:00Z