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Synthetic biology of antimicrobial discoveryStructural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide SynthetasesThe Missing Linker: A Dimerization Motif Located within Polyketide Synthase ModulesTrapping the dynamic acyl carrier protein in fatty acid biosynthesisManipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactionsEnzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.Natural products as chemical probesEmerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds.Ten-Minute Protein Purification and Surface Tethering for Continuous-Flow Biocatalysis.Programming of erythromycin biosynthesis by a modular polyketide synthaseThe Mycobacterium tuberculosis FAS-II dehydratases and methyltransferases define the specificity of the mycolic acid elongation complexes.Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactumAnalysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases.Adenylate-forming enzymes.Engineering polyketide synthases and nonribosomal peptide synthetases.Endogenous cross-talk of fungal metabolites.Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthaseGenome mining reveals unlocked bioactive potential of marine Gram-negative bacteria.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategyThe complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis.Harnessing natural product assembly lines: structure, promiscuity, and engineering.The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzymeComplex small-molecule architectures regulate phenotypic plasticity in a nematodeStructural analysis of protein-protein interactions in type I polyketide synthasesBacillus amyloliquefaciens GA1 as a source of potent antibiotics and other secondary metabolites for biocontrol of plant pathogens.Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis.Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis.Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways.Flexibility and reactivity in promiscuous enzymes.Developing new antibacterials through natural product research.Steps towards the synthetic biology of polyketide biosynthesis.SBSPKSv2: structure-based sequence analysis of polyketide synthases and non-ribosomal peptide synthetases.Oxidative Cyclization in Natural Product BiosynthesisAntimicrobial Activity of Bacillus amyloliquefaciens ANT1 Toward Pathogenic Bacteria and Mold: Effects on Biofilm Formation.Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A.A fungal ketoreductase domain that displays substrate-dependent stereospecificity.Inhibition of cereulide toxin synthesis by emetic Bacillus cereus via long-chain polyphosphates.Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The chemical biology of modular biosynthetic enzymes.
@en
The chemical biology of modular biosynthetic enzymes.
@nl
type
label
The chemical biology of modular biosynthetic enzymes.
@en
The chemical biology of modular biosynthetic enzymes.
@nl
prefLabel
The chemical biology of modular biosynthetic enzymes.
@en
The chemical biology of modular biosynthetic enzymes.
@nl
P2860
P356
P1476
The chemical biology of modular biosynthetic enzymes.
@en
P2093
Michael D Burkart
P2860
P304
P356
10.1039/B805115C
P577
2009-03-27T00:00:00Z