Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.
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Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.Forward Genetic Screen in Caenorhabditis elegans Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes.What we know about TMEM106B in neurodegeneration.Subcellular Trafficking of Mammalian Lysosomal Proteins: An Extended View.C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.The lysosomal function of progranulin, a guardian against neurodegeneration
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Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 April 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Increased expression of the fr ...... dent alterations in lysosomes.
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Increased expression of the fr ...... dent alterations in lysosomes.
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Increased expression of the fr ...... dent alterations in lysosomes.
@en
Increased expression of the fr ...... dent alterations in lysosomes.
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Increased expression of the fr ...... dent alterations in lysosomes.
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Increased expression of the fr ...... dent alterations in lysosomes.
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P2093
P2860
P356
P1476
Increased expression of the fr ...... dent alterations in lysosomes.
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P2093
Alice S Chen-Plotkin
Johanna I Busch
Nimansha Jain
R Tyler Skrinak
Rakshita A Charan
Travis L Unger
P2860
P304
P356
10.1093/HMG/DDW127
P577
2016-04-28T00:00:00Z