Inhibition of RAS function through targeting an allosteric regulatory site.
about
Monobodies and other synthetic binding proteins for expanding protein scienceSelective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.Affimer proteins are versatile and renewable affinity reagentsAn engineered protein antagonist of K-Ras/B-Raf interaction.Modeling of RAS complexes supports roles in cancer for less studied partners.RAS Proteins and Their Regulators in Human Disease.A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.Phosphorylation of the C-Raf N-region promotes Raf dimerization.A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation.Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation.K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions.Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity.Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.Recent advances in the biology and therapy of medullary thyroid carcinoma.RAS signaling: Divide and conquer.A "Tug of War" Maintains a Dynamic Protein-Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane.Generating FN3-Based Affinity Reagents Through Phage DisplayRAS variant signallingFacile target validation in an animal model with intracellularly expressed monobodies
P2860
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P2860
Inhibition of RAS function through targeting an allosteric regulatory site.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Inhibition of RAS function through targeting an allosteric regulatory site.
@en
Inhibition of RAS function through targeting an allosteric regulatory site.
@nl
type
label
Inhibition of RAS function through targeting an allosteric regulatory site.
@en
Inhibition of RAS function through targeting an allosteric regulatory site.
@nl
prefLabel
Inhibition of RAS function through targeting an allosteric regulatory site.
@en
Inhibition of RAS function through targeting an allosteric regulatory site.
@nl
P2093
P2860
P50
P356
P1476
Inhibition of RAS function through targeting an allosteric regulatory site
@en
P2093
Akiko Koide
Ankit Gupta
Dianicha Santana
Erika Herrero-Garcia
Evan Dowdell
Frank Sicheri
Hugo Lavoie
Irina Dementieva
Jacqueline Cobbert
P2860
P2888
P356
10.1038/NCHEMBIO.2231
P577
2016-11-07T00:00:00Z