Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. - Wikidata - awgldk - TriplyDB

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

http://www.wikidata.org/entity/Q37543714

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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal The AMPK agonist AICAR inhibits TGF-β1 induced activation of kidney myofibroblasts Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters Artemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do?Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis Metformin as a cellular protector; a synoptic view of modern evidences Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A).Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199.Dissecting the role of AMP-activated protein kinase in human diseases.Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer.microRNAs and cancer metabolism reprogramming: the paradigm of metformin Metformin and the risk of cancer in type 2 diabetes: methodological challenges and perspectives Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta Drugs acting on homeostasis: challenging cancer cell adaptation.Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium.Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.Deregulated proliferation and differentiation in brain tumors.Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current Metformin use and lung cancer risk in patients with diabetes.2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice.Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor.AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic.Impact of AMP-Activated Protein Kinase α1 Deficiency on Tissue Injury following Unilateral Ureteral Obstruction.Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?The double trouble of metabolic diseases: the diabetes-cancer link.Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR).The new biology of diabetes.AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells.Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids eIF3 controls cell size independently of S6K1-activity.Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.

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Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.

http://www.wikidata.org/entity/Q37543714

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 January 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Discrete mechanisms of mTOR an ...... agonists independent of AMPK.

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Discrete mechanisms of mTOR an ...... agonists independent of AMPK.

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type

label

Discrete mechanisms of mTOR an ...... agonists independent of AMPK.

@en

Discrete mechanisms of mTOR an ...... agonists independent of AMPK.

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prefLabel

Discrete mechanisms of mTOR an ...... agonists independent of AMPK.

@en

Discrete mechanisms of mTOR an ...... agonists independent of AMPK.

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PNAS.1311121111

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Proceedings of the National Academy of Sciences of the United States of America

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Discrete mechanisms of mTOR an ...... K agonists independent of AMPK

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Ady Kendler

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Ashish Kumar

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Biplab Dasgupta

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Brian Quinn

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Christopher McPherson

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Gregory A Grabowski

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Jeroen Poels

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Rishi Raj Chhipa

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Ronald E Warnick

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Sara Yachyshin

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P2860

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

AMPK phosphorylation of raptor mediates a metabolic checkpoint

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

TSC2 mediates cellular energy response to control cell growth and survival

Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis

Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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E435-44

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scholarly article

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10.1073/PNAS.1311121111

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4

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111

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Koenraad K Norga

Matthew Wortman

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2014-01-13T00:00:00Z

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259961238

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24474794

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3910576

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