Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
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Overview of the Diagnostic Methods Used in the Field for Human African Trypanosomiasis: What Could Change in the Next Years?Exploiting the Achilles' heel of membrane trafficking in trypanosomesMelarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the CongoSpecific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African TrypanosomiasisAn Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma bruceiNew Trypanosoma evansi Type B Isolates from Ethiopian Dromedary CamelsPentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPaseResistance-resistant antibioticsTransport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma bruceiDrug resistance in eukaryotic microorganisms.Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis.The recent escalation in strength of pyrethroid resistance in Anopheles coluzzi in West Africa is linked to increased expression of multiple gene familiesHigh-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.How do antimalarial drugs reach their intracellular targets?Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates.Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategyAquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.Aquaporins with anion/monocarboxylate permeability: mechanisms, relevance for pathogen-host interactions.Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.The animal trypanosomiases and their chemotherapy: a reviewStructural and evolutionary divergence of aquaporins in parasites (Review).9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance.SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts.Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts.Design and synthesis of a series of truncated neplanocin fleximers.The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins.Silver and Nitrate Oppositely Modulate Antimony Susceptibility through Aquaglyceroporin 1 in Leishmania (Viannia) Species.Transporters of Trypanosoma brucei-phylogeny, physiology, pharmacology.Could specific cell targeting overcome resistance associated with current treatments for African trypanosomiasis?Isometamidium chloride and homidium chloride fail to cure mice infected with Ethiopian Trypanosoma evansi type A and B
P2860
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P2860
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
description
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name
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@en
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@nl
type
label
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@en
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@nl
prefLabel
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@en
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@nl
P2093
P2860
P50
P356
P1476
Trypanosoma brucei aquaglycero ...... of resistance to these drugs.
@en
P2093
Annette MacLeod
C Michael R Turner
Caroline Clucas
Ibrahim A Teka
Manal J Natto
Michael P Barrett
Philipp Ludin
Rebecca S Lee
Richard J S Burchmore
P2860
P304
P356
10.1093/JAC/DKT442
P407
P50
P577
2013-11-13T00:00:00Z