Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
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Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolideAtlas on substrate recognition subunits of CRL2 E3 ligasesAnti-angiogenic therapies for metastatic colorectal cancer: current and future perspectivesPosttranscriptional regulation of cancer traits by HuRProteomic profiling of follicular and papillary thyroid tumorsQ6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinomaKCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacologyAloe-emodin suppresses hypoxia-induced retinal angiogenesis via inhibition of HIF-1α/VEGF pathwayThe role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile.Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumabHif1α down-regulation is associated with transposition of great arteries in mice treated with a retinoic acid antagonist.MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.SHARP1 suppresses angiogenesis of endometrial cancer by decreasing hypoxia-inducible factor-1α levelOverexpression of carbonic anhydrase and HIF-1α in Wilms tumours.The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathwayClinicopathologic significance of HIF-1α, CXCR4, and VEGF expression in colon cancer.Correlation between long-term aspirin use and F-fluorodeoxyglucose uptake in colorectal cancer measured by PET/CT.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?Superior efficacy of tumor cell vaccines grown in physiologic oxygenExpression profiling for bladder cancer: strategies to uncover prognostic factors.The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers.Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing.Hypoxia and lineage specification of cell line-derived colorectal cancer stem cellsThe G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytesPronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence.Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule.Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo.Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effectsExpression of hypoxic markers and their prognostic significance in soft tissue sarcomaNovel and emerging targeted-based cancer therapy agents and methods.Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α.Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxiaHuman CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progressionA potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors.A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cellsMicrotubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy.Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma PatientsActivation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells.Tissue dynamics spectroscopy for phenotypic profiling of drug effects in three-dimensional culture.
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P2860
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 27 August 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
@en
Targeting the hypoxia-inducible factor
@nl
type
label
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
@en
Targeting the hypoxia-inducible factor
@nl
prefLabel
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
@en
Targeting the hypoxia-inducible factor
@nl
P2860
P1476
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
@en
P2093
Margaret Ashcroft
P2860
P356
10.1017/S1462399409001173
P577
2009-08-27T00:00:00Z