The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants.
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Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disordersNeurobiology of chronic mild stress: parallels to major depressionCannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's DiseaseDeficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress.Endocannabinoid signalling modulates susceptibility to traumatic stress exposureEndocannabinoids differentially modulate synaptic plasticity in rat hippocampal CA1 pyramidal neuronsEndocannabinoids and striatal function: implications for addiction-related behavioursMonoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling.Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentationDisruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructureInvolvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoidsGenetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus.Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey.Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation.Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence.Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity.Ultrastructural evidence for synaptic contacts between cortical noradrenergic afferents and endocannabinoid-synthesizing post-synaptic neurons.Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathwayAlterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out miceAcute stress increases circulating anandamide and other N-acylethanolamines in healthy humans.Neurobiological Interactions Between Stress and the Endocannabinoid System.Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain modelCyclooxygenase-2 inhibition reduces stress-induced affective pathology.Translational evidence for the involvement of the endocannabinoid system in stress-related psychiatric illnessesModulating the modulators: interaction of brain norepinephrine and cannabinoids in stress.Resilience to meet the challenge of addiction: psychobiology and clinical considerations.Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses.Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.Novel discoveries in understanding the complexities of epilepsy and major depression.Cannabinoid conditioned reward and aversion: behavioral and neural processes.Endocannabinoids and stress.CB1 receptor antagonists: new discoveries leading to new perspectives.Opposing local effects of endocannabinoids on the activity of noradrenergic neurons and release of noradrenaline: relevance for their role in depression and in the actions of CB(1) receptor antagonists.Selective MAO-B inhibitors: a lesson from natural products.Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapsesThe anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway.Schizophrenia and depression, two poles of endocannabinoid system deregulation.Cannabinoid Modulation of the Stressed Hippocampus.
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P2860
The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 September 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The therapeutic potential of t ...... ovel class of antidepressants.
@en
The therapeutic potential of t ...... ovel class of antidepressants.
@nl
type
label
The therapeutic potential of t ...... ovel class of antidepressants.
@en
The therapeutic potential of t ...... ovel class of antidepressants.
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prefLabel
The therapeutic potential of t ...... ovel class of antidepressants.
@en
The therapeutic potential of t ...... ovel class of antidepressants.
@nl
P2093
P1476
The therapeutic potential of t ...... ovel class of antidepressants.
@en
P2093
Boris B Gorzalka
Cecilia J Hillard
Francis R Bambico
Matthew N Hill
Sachin Patel
P304
P356
10.1016/J.TIPS.2009.06.006
P577
2009-09-03T00:00:00Z