ABC transporters: a riddle wrapped in a mystery inside an enigma.
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Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIICDependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductanceProviding a molecular mechanism for P-glycoprotein; why would I bother?Visualizing functional motions of membrane transporters with molecular dynamics simulationsThermodynamics of ABC transportersStudies of the Maltose Transport System Reveal a Mechanism for Coupling ATP Hydrolysis to Substrate Translocation without Direct Recognition of SubstrateCrystal structure of the maltose transporter in a pretranslocation intermediate stateArginine 116 stabilizes the entrance to the metal ion-binding site of the MntC proteinTuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin bindersTranscriptome-based identification of ABC transporters in the western tarnished plant bug Lygus hesperusThe Nucleotide-Free State of the Multidrug Resistance ABC Transporter LmrA: Sulfhydryl Cross-Linking Supports a Constant Contact, Head-to-Tail Configuration of the Nucleotide-Binding DomainsStructural consequences of ATP hydrolysis on the ABC transporter NBD dimer: molecular dynamics studies of HlyB.Fungal PDR transporters: Phylogeny, topology, motifs and function.The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and developmentSolution NMR studies of periplasmic binding proteins and their interaction partnersA distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formationTranslocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleasesAn interaction between the Walker A and D-loop motifs is critical to ATP hydrolysis and cooperativity in bacteriophage T4 Rad50Dynamics of alpha-helical subdomain rotation in the intact maltose ATP-binding cassette transporterAdvances in the molecular understanding of biological zinc transport.An asymmetric post-hydrolysis state of the ABC transporter ATPase dimer.Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expressionMolecular-dynamics simulations of the ATP/apo state of a multidrug ATP-binding cassette transporter provide a structural and mechanistic basis for the asymmetric occluded stateGemcitabine Cytotoxicity: Interaction of Efflux and Deamination.Plasmodium knowlesi genome sequences from clinical isolates reveal extensive genomic dimorphismEfficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studiesConformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2.Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy.Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil DomainThe ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely togetherDisruption of the bacteriophage T4 Mre11 dimer interface reveals a two-state mechanism for exonuclease activityD-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domainP-glycoprotein is fully active after multiple tryptophan substitutionsThe central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.On the origin of large flexibility of P-glycoprotein in the inward-facing stateMultidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites.Association/dissociation of the nucleotide-binding domains of the ATP-binding cassette protein MsbA measured during continuous hydrolysisToward Determining ATPase Mechanism in ABC Transporters: Development of the Reaction Path-Force Matching QM/MM Method.The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle.
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ABC transporters: a riddle wrapped in a mystery inside an enigma.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@en
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@nl
type
label
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@en
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@nl
prefLabel
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@en
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@nl
P1476
ABC transporters: a riddle wrapped in a mystery inside an enigma.
@en
P2093
Peter M Jones
P304
P356
10.1016/J.TIBS.2009.06.004
P577
2009-09-11T00:00:00Z