Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
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RNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionRecent findings on the mechanisms involved in tenofovir resistance.Alternate polypurine tracts (PPTs) affect the rous sarcoma virus RNase H cleavage specificity and reveal a preferential cleavage following a GA dinucleotide sequence at the PPT-U3 junction.Rapid screening of HIV reverse transcriptase and integrase inhibitors.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Mutations in the U5 sequences adjacent to the primer binding site do not affect tRNA cleavage by rous sarcoma virus RNase H but do cause aberrant integrations in vivoViral reverse transcriptases show selective high affinity binding to DNA-DNA primer-templates that resemble the polypurine tract.Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H functionAlternate polypurine tracts affect rous sarcoma virus integration in vivo.Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.Rous sarcoma virus (RSV) integration in vivo: a CA dinucleotide is not required in U3, and RSV linear DNA does not autointegrate.Mutations in the U5 region adjacent to the primer binding site affect tRNA cleavage by human immunodeficiency virus type 1 reverse transcriptase in vivoThe effects of alternate polypurine tracts (PPTs) and mutations of sequences adjacent to the PPT on viral replication and cleavage specificity of the Rous sarcoma virus reverse transcriptase.Integration of rous sarcoma virus DNA: a CA dinucleotide is not required for integration of the U3 end of viral DNA.(DNS)C: a fluorescent, environmentally sensitive cytidine derivative for the direct detection of GGG triad sequences.RNase H-mediated cleavage of the template strandRNase H-mediated degradation of the template strandHow Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir.
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Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Effects of mutations in the G ...... plication and RNase H cleavage
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Effects of mutations in the G ...... lication and RNase H cleavage.
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type
label
Effects of mutations in the G ...... plication and RNase H cleavage
@en
Effects of mutations in the G ...... lication and RNase H cleavage.
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prefLabel
Effects of mutations in the G ...... plication and RNase H cleavage
@en
Effects of mutations in the G ...... lication and RNase H cleavage.
@nl
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Effects of mutations in the G ...... plication and RNase H cleavage
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Eddy Arnold
John G Julias
Stefan G Sarafianos
W Gregory Alvord
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13315-13324
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10.1128/JVI.78.23.13315-13324.2004
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2004-12-01T00:00:00Z