Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a. - Wikidata - awgldk - TriplyDB

Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.

Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.

http://www.wikidata.org/entity/Q37597067

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The Calcium-Sensing Receptor and Integrins in Cellular Differentiation and Migration The alliance of mesenchymal stem cells, bone, and diabetes The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis Adult tissue sources for new β cells.CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots.Repurposing cAMP-modulating medications to promote β-cell replication.Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway.Carriers of loss-of-function mutations in EXT display impaired pancreatic beta-cell reserve due to smaller pancreas volume Recent progress in studies of factors that elicit pancreatic β-cell expansion GGCX and VKORC1 inhibit osteocalcin endocrine functions.Effects of moderate amounts of barley in late pregnancy on growth, glucose metabolism and osteoarticular status of pre-weaning horses Association between osteocalcin and glucose metabolism: a meta-analysis.Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation The effects of acute hyperinsulinemia on bone metabolism.An overview of the metabolic functions of osteocalcin Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues New insights into the biology of osteocalcin.GPRC6a is not required for the effects of a high-protein diet on body weight in mice Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.Inter-organ communication and regulation of beta cell function Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells Searching for additional endocrine functions of the skeleton: genetic approaches and implications for therapeutics.Osteocalcin is necessary and sufficient to maintain muscle mass in older mice.The association between bone turnover markers and microvascular complications of type 2 diabetes.Insulin and bone: Recent developments.GPRC6A: Jack of all metabolism (or master of none).A four-season molecule: osteocalcin. Updates in its physiological roles.Osteocalcin: an osteoblast-derived polypeptide hormone that modulates whole body energy metabolism.Bone, brain & beyond.Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance.Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women.An overview of osteocalcin progress.Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.Orientation and conformation of osteocalcin adsorbed onto calcium phosphate and silica surfaces.Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass.Advances in β cell replacement and regeneration strategies for treating diabetes Bone-Derived Factors: A New Gateway to Regulate Glycemia.Interorgan Crosstalk Contributing to β-Cell Dysfunction.

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Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a.

http://www.wikidata.org/entity/Q37597067

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 05 September 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

@en

Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

@nl

type

label

Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

@en

Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

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prefLabel

Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

@en

Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

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Osteocalcin promotes β-cell pr ...... and adulthood through Gprc6a.

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Gerard Karsenty

http://www.w3.org/2001/XMLSchema#string

Jianwen Wei

http://www.w3.org/2001/XMLSchema#string

Nina Suda

http://www.w3.org/2001/XMLSchema#string

Patricia Ducy

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Timothy Hanna

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P2860

Endocrine regulation of energy metabolism by the skeleton

Identification of a novel extracellular cation-sensing G-protein-coupled receptor

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.

The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.

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1021-1031

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scholarly article

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10.2337/DB13-0887

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3

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63

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2013-09-05T00:00:00Z

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256452202

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24009262

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3931403

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