Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.
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Oncogenes strike a balance between cellular growth and homeostasisGenes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal OncogenesisIntegrating canonical and metabolic signalling programmes in the regulation of T cell responsesCo-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancerLipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and HypoxiaThe ever-expanding role of HIF in tumour and stromal biologyMetabolic pathways promoting cancer cell survival and growthMetformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent BiosynthesisDissecting the role of AMP-activated protein kinase in human diseases.GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activationThe distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.Chondroitin sulfate proteoglycan CSPG4 as a novel hypoxia-sensitive marker in pancreatic tumorsRacial disparity in metabolic regulation of cancer.LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?Metformin: a modulator of bevacizumab activity in cancer? A case reportUnderexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.Regulation of glucose metabolism by p62/SQSTM1 through HIF1αMeasuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer.LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer.The double-edged sword of AMPK signaling in cancer and its therapeutic implications.Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells.HIF-1 in cancer therapy: two decade long story of a transcription factor.Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers.Differential effects of AMPK agonists on cell growth and metabolismOxygen availability and metabolic adaptations.Preclinical Development of a Nontoxic Oral Formulation of Monoethanolamine, a Lipid Precursor, for Prostate Cancer Treatment.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.LKB1 promotes metabolic flexibility in response to energy stress.MYC and AMPK-Save Energy or Die!Role of long non-coding RNAs in glucose metabolism in cancer.
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Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 03 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@en
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@nl
type
label
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@en
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@nl
prefLabel
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@en
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@nl
P2093
P2860
P356
P1476
Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.
@en
P2093
Bozena Samborska
Brandon Faubert
Daina Avizonis
David B Shackelford
Orval A Mamer
Reuben J Shaw
Robert U Svensson
Russell G Jones
Said Izreig
Takla Griss
P2860
P304
P356
10.1073/PNAS.1312570111
P407
P577
2014-02-03T00:00:00Z