Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. - Wikidata - awgldk - TriplyDB

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

http://www.wikidata.org/entity/Q37599925

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Oncogenes strike a balance between cellular growth and homeostasis Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis Integrating canonical and metabolic signalling programmes in the regulation of T cell responses Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia The ever-expanding role of HIF in tumour and stromal biology Metabolic pathways promoting cancer cell survival and growth Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis Dissecting the role of AMP-activated protein kinase in human diseases.GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.Chondroitin sulfate proteoglycan CSPG4 as a novel hypoxia-sensitive marker in pancreatic tumors Racial disparity in metabolic regulation of cancer.LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small-cell lung cancer (NSCLC) cells.Is 5´-AMP-Activated Protein Kinase Both Jekyll and Hyde in Bladder Cancer?Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?Metformin: a modulator of bevacizumab activity in cancer? A case report Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.Regulation of glucose metabolism by p62/SQSTM1 through HIF1α Measuring Bioenergetics in T Cells Using a Seahorse Extracellular Flux Analyzer.LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism.The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer.The double-edged sword of AMPK signaling in cancer and its therapeutic implications.Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells.HIF-1 in cancer therapy: two decade long story of a transcription factor.Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers.Differential effects of AMPK agonists on cell growth and metabolism Oxygen availability and metabolic adaptations.Preclinical Development of a Nontoxic Oral Formulation of Monoethanolamine, a Lipid Precursor, for Prostate Cancer Treatment.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.LKB1 promotes metabolic flexibility in response to energy stress.MYC and AMPK-Save Energy or Die!Role of long non-coding RNAs in glucose metabolism in cancer.

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Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α.

http://www.wikidata.org/entity/Q37599925

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 03 February 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@en

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@nl

type

label

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@en

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@nl

prefLabel

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@en

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@nl

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PNAS.1312570111

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Loss of the tumor suppressor L ...... ng of cancer cells via HIF-1α.

@en

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Bozena Samborska

http://www.w3.org/2001/XMLSchema#string

Brandon Faubert

http://www.w3.org/2001/XMLSchema#string

Daina Avizonis

http://www.w3.org/2001/XMLSchema#string

David B Shackelford

http://www.w3.org/2001/XMLSchema#string

Orval A Mamer

http://www.w3.org/2001/XMLSchema#string

Reuben J Shaw

http://www.w3.org/2001/XMLSchema#string

Robert U Svensson

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Russell G Jones

http://www.w3.org/2001/XMLSchema#string

Said Izreig

http://www.w3.org/2001/XMLSchema#string

Takla Griss

http://www.w3.org/2001/XMLSchema#string

P2860

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

Brick by brick: metabolism and tumor cell growth

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

Spare respiratory capacity, oxidative stress and excitotoxicity

The LKB1 tumor suppressor negatively regulates mTOR signaling

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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2554-2559

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scholarly article

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10.1073/PNAS.1312570111

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7

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111

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Emma E. Vincent

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2014-02-03T00:00:00Z

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260253948

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24550282

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3932920

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