Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?
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Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatmentAdvances in targeting signal transduction pathwaysGene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis.Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway.Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis.Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease.Fetal brain mTOR signaling activation in tuberous sclerosis complex.The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis.Autophagy and amino acid metabolism in the brain: implications for epilepsy.Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.The expanding relevance of nuclear mTOR in carcinogenesis.One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.Rapamycin for treatment of epilepsy: antiseizure, antiepileptogenic, both, or neither?Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat.Neural Progenitor Cells Rptor Ablation Impairs Development but Benefits to Seizure-Induced Behavioral Abnormalities.Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy.Before epilepsy unfolds: finding the epileptogenesis switch.
P2860
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P2860
Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 June 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Regulation of cell death and e ...... (mTOR): a double-edged sword?
@en
Regulation of cell death and epileptogenesis by the mammalian target of rapamycin
@nl
type
label
Regulation of cell death and e ...... (mTOR): a double-edged sword?
@en
Regulation of cell death and epileptogenesis by the mammalian target of rapamycin
@nl
prefLabel
Regulation of cell death and e ...... (mTOR): a double-edged sword?
@en
Regulation of cell death and epileptogenesis by the mammalian target of rapamycin
@nl
P2093
P2860
P356
P1433
P1476
Regulation of cell death and e ...... (mTOR): a double-edged sword?
@en
P2093
Ling-Hui Zeng
Michael Wong
Nicholas R Rensing
Sharon McDaniel
P2860
P304
P356
10.4161/CC.9.12.11866
P577
2010-06-15T00:00:00Z