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Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivoAPP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functionsDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaAPP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantIncreased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.Proteomic characterization of a mouse model of familial Danish dementia.APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.Increased AβPP processing in familial Danish dementia patients.Amyloid peptides ABri and ADan show differential neurotoxicity in transgenic Drosophila models of familial British and Danish dementia.BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and NeurodegenerationAmyloid and intracellular accumulation of BRI2.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Modeling familial British and Danish dementia.
@en
Modeling familial British and Danish dementia.
@nl
type
label
Modeling familial British and Danish dementia.
@en
Modeling familial British and Danish dementia.
@nl
prefLabel
Modeling familial British and Danish dementia.
@en
Modeling familial British and Danish dementia.
@nl
P2093
P2860
P1476
Modeling familial British and Danish dementia.
@en
P2093
Bernardino Ghetti
Holly J Garringer
Jill Murrell
Luciano D'Adamio
Ruben Vidal
P2860
P304
P356
10.1007/S00429-009-0221-9
P577
2009-09-25T00:00:00Z