Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.
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Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient miceDeletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient miceQuantitation of the rates of hepatic and intestinal cholesterol synthesis in lysosomal acid lipase-deficient mice before and during treatment with ezetimibe.Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse.Long term substrate reduction therapy with ezetimibe alone or associated with statins in three adult patients with lysosomal acid lipase deficiency.
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Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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P2093
P2860
P1476
Ezetimibe markedly attenuates ...... esteryl ester storage disease.
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P2093
Adam M Lopez
Jen-Chieh Chuang
Kenneth S Posey
Stephen D Turley
P2860
P304
P356
10.1016/J.BBRC.2013.12.096
P407
P577
2013-12-25T00:00:00Z