CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
about
Cullin family proteins and tumorigenesis: genetic association and molecular mechanismsIntegrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast CancerCUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma.Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system.Cullin E3 ligases and their rewiring by viral factorsThe COP9 signalosome is vital for timely repair of DNA double-strand breaks.Cul4A overexpression associated with Gli1 expression in malignant pleural mesotheliomaCUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transitionAiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cellsGenomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.miR-181a-2 downregulates the E3 ubiquitin ligase CUL4A transcript and promotes cell proliferation.DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle.DDB1 and CUL4 associated factor 11 (DCAF11) mediates degradation of Stem-loop binding protein at the end of S phaseKnockdown of CUL4A inhibits invasion and induces apoptosis in osteosarcoma cells.Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.Activation of TNF-α/NF-κB axis enhances CRL4BDCAF11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells.Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway.Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.
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CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 February 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
@en
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases.
@nl
type
label
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
@en
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases.
@nl
prefLabel
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
@en
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases.
@nl
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P921
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CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases
@en
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Puneet Sharma
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P304
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10.1098/RSOB.130217
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P577
2014-02-12T00:00:00Z