The 26 S proteasome: from basic mechanisms to drug targeting.
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Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiologyRole of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanismStructural basis for the unfolding of anthrax lethal factor by protective antigen oligomersAn inducible chaperone adapts proteasome assembly to stress.Aging and immune function: molecular mechanisms to interventionsProteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulationCharacterization of the 26S proteasome network in Plasmodium falciparumClinical activity of bortezomib in relapsed/refractory MALT lymphomas: results of a phase II study of the International Extranodal Lymphoma Study Group (IELSG).TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cellsDifferential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.Protein homeostasis and aging: The importance of exquisite quality control.Genome-wide approaches to systematically identify substrates of the ubiquitin-proteasome pathwayProfiling of protein interaction networks of protein complexes using affinity purification and quantitative mass spectrometry.Chaperone-mediated autophagy in protein quality controlSkeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.Degradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1.LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinomaProtein aggregation and degradation mechanisms in neurodegenerative diseasesMisfolded proteins: from little villains to little helpers in the fight against cancer.Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation.Failure of amino acid homeostasis causes cell death following proteasome inhibition.Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitorsThe protective effects of the proteasome inhibitor bortezomib (velcade) on ischemia-reperfusion injury in the rat retina.Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation.Disruption of a mitochondrial protease machinery in Plasmodium falciparum is an intrinsic signal for parasite cell death.Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.Ubiquitination and proteolysis in acute lung injuryThe ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discoveryPeptidomic analysis of HEK293T cells: effect of the proteasome inhibitor epoxomicin on intracellular peptidesReduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20S proteasomeActivity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells.Revisiting the role of the immunoproteasome in the activation of the canonical NF-κB pathway.Noncompetitive modulation of the proteasome by imidazoline scaffolds overcomes bortezomib resistance and delays MM tumor growth in vivo.Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopesActivity-based imaging probes of the proteasome.Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction in chaperone interactions.Inhibition of the human proteasome by imidazoline scaffolds.
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The 26 S proteasome: from basic mechanisms to drug targeting.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The 26 S proteasome: from basic mechanisms to drug targeting.
@en
The 26 S proteasome: from basic mechanisms to drug targeting.
@nl
type
label
The 26 S proteasome: from basic mechanisms to drug targeting.
@en
The 26 S proteasome: from basic mechanisms to drug targeting.
@nl
prefLabel
The 26 S proteasome: from basic mechanisms to drug targeting.
@en
The 26 S proteasome: from basic mechanisms to drug targeting.
@nl
P2860
P356
P1476
The 26 S proteasome: from basic mechanisms to drug targeting.
@en
P2093
P2860
P304
33713-33718
P356
10.1074/JBC.R109.018481
P407
P577
2009-10-07T00:00:00Z