Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting
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Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transpositionAmplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaksGeneral method for quantifying base adducts in specific mammalian genes.Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cellsGene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakageOverreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.The selection of high-producing cell lines using flow cytometry and cell sorting.Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneityAberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma.Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle.Ubiquitous, heritable damage in cell populations that survive treatment with methotrexate.Generalized principles of stochasticity can be used to control dynamic heterogeneityConceptualizing a tool to optimize therapy based on dynamic heterogeneity.Demethylation enhances removal of pyrimidine dimers from the overall genome and from specific DNA sequences in Chinese hamster ovary cellsFormation of an inverted duplication can be an initial step in gene amplification.Transient inhibition of DNA synthesis results in increased dihydrofolate reductase synthesis and subsequent increased DNA content per cellInefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles.Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism.Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment.Intragenomic heterogeneity of DNA damage formation and repair: a review of cellular responses to covalent drug DNA interaction.c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene.
P2860
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P2860
Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1983
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Rapid spontaneous dihydrofolat ...... escence-activated cell sorting
@en
Rapid spontaneous dihydrofolat ...... scence-activated cell sorting.
@nl
type
label
Rapid spontaneous dihydrofolat ...... escence-activated cell sorting
@en
Rapid spontaneous dihydrofolat ...... scence-activated cell sorting.
@nl
prefLabel
Rapid spontaneous dihydrofolat ...... escence-activated cell sorting
@en
Rapid spontaneous dihydrofolat ...... scence-activated cell sorting.
@nl
P2093
P2860
P356
P1476
Rapid spontaneous dihydrofolat ...... escence-activated cell sorting
@en
P2093
R N Johnston
R T Schimke
S M Beverley
P2860
P304
P356
10.1073/PNAS.80.12.3711
P407
P577
1983-06-01T00:00:00Z