Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks
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RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genesTelomere dysfunction and chromosome instabilityPrognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer.Intragenic amplification and formation of extrachromosomal small circular DNA molecules from the PIP gene on chromosome 7 in primary breast carcinomasIsolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells.Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumorsA novel gene amplification system in yeast based on double rolling-circle replication.Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells.Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis.Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression.Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cellsPerformance of a single assay for both type III and type VI TMPRSS2:ERG fusions in noninvasive prediction of prostate biopsy outcome.DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.The emergence of resistance to targeted cancer therapeutics.Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells.The role of DNA breaks in genomic instability and tumorigenesis.Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis.Engineering targeted chromosomal amplifications in human breast epithelial cellsDisparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesisChromosomal instability in oral cancer cells.Mechanisms of telomere loss and their consequences for chromosome instability.Association between sister chromatid exchange and double minute chromosomes in human tumor cellsAnalysis of re-replication from deregulated origin licensing by DNA fiber spreadingMethotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells.Genetic conflicts: the usual suspects and beyond.Corrections for mRNA extraction and sample normalization errors find increased mRNA levels may compensate for cancer haplo-insufficiency.Aberrations of ERBB2 and TOP2A genes in breast cancer.Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells.Structure of a palindromic amplicon junction implicates microhomology-mediated end joining as a mechanism of sister chromatid fusion during gene amplification.Gene amplification in human cells knocked down for RAD54c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene.Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells.Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rearrangements.Shaping of tumor and drug-resistant genomes by instability and selection.
P2860
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P2860
Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks
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2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Amplification of the human dih ...... initiated by chromosome breaks
@ast
Amplification of the human dih ...... initiated by chromosome breaks
@en
type
label
Amplification of the human dih ...... initiated by chromosome breaks
@ast
Amplification of the human dih ...... initiated by chromosome breaks
@en
prefLabel
Amplification of the human dih ...... initiated by chromosome breaks
@ast
Amplification of the human dih ...... initiated by chromosome breaks
@en
P2093
P2860
P356
P1476
Amplification of the human dih ...... initiated by chromosome breaks
@en
P2093
C L Friedman
J L Hamlin
L D Mesner
M J Singer
P2860
P304
P356
10.1073/PNAS.130194897
P407
P577
2000-07-01T00:00:00Z