Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)
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Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer.Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug UsesThe Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIPL.Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death.Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways.Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT PathwayThioridazine Sensitizes Esophageal Carcinoma Cell Lines to Radiotherapy-Induced Apoptosis In Vitro and In Vivo.Pitavastatin suppressed liver cancer cells in vitro and in vivoInhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells.Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression.Relationship between prolactin, breast cancer risk, and antipsychotics in patients with schizophrenia: a critical review.Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors.Targeting Lung Cancer Stem Cells with Antipsychological Drug ThioridazineFTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells.A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia.NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.Effect of thioridazine on antioxidant status of HEMn-DP melanocytes.YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cellsMethylglyoxal-induced apoptosis is dependent on the suppression of c-FLIPL expression via down-regulation of p65 in endothelial cells.BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression.
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Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Antipsychotic agent thioridazi ...... regulation of Mcl-1 and c-FLIP
@nl
Antipsychotic agent thioridazi ...... ulation of Mcl-1 and c-FLIP(L)
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type
label
Antipsychotic agent thioridazi ...... regulation of Mcl-1 and c-FLIP
@nl
Antipsychotic agent thioridazi ...... ulation of Mcl-1 and c-FLIP(L)
@en
prefLabel
Antipsychotic agent thioridazi ...... regulation of Mcl-1 and c-FLIP
@nl
Antipsychotic agent thioridazi ...... ulation of Mcl-1 and c-FLIP(L)
@en
P2093
P2860
P356
P1476
Antipsychotic agent thioridazi ...... ulation of Mcl-1 and c-FLIP(L)
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P2093
P2860
P2888
P356
10.1038/CDDIS.2014.35
P577
2014-02-20T00:00:00Z
P5875
P6179
1049843444