Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.
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Repurposing metformin: an old drug with new tricks in its binding pocketsDiabetes mellitus and metformin in hepatocellular carcinomaBetter Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and LifespanThe role of STAT3 in autophagyAutophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin AnalogRepurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastomaMetformin as a cellular protector; a synoptic view of modern evidencesMetformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A.Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer.Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells.Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent.Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma.Metformin inhibits tumor growth by regulating multiple miRNAs in human cholangiocarcinoma.Metformin inhibits growth of human glioblastoma cells and enhances therapeutic responseSTAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells.Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer.Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathwaysAMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cellHigh Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells.Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis.Tumor growth suppression by inhibiting both autophagy and STAT3 signaling in HNSCC.Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy.PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery.Resveratrol and STAT inhibitor enhance autophagy in ovarian cancer cells.The Influence of Diabetes Mellitus and Metformin on Distant Metastases in Oropharyngeal Cancer: A Multicenter StudyMorphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: pathogSTAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signalingMetformin targets multiple signaling pathways in cancer.Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling.Dihydromyricetin promotes autophagy and apoptosis through ROS-STAT3 signaling in head and neck squamous cell carcinoma.Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway.Metformin and esophageal cancer risk in Taiwanese patients with type 2 diabetes mellitus.mTOR: a pharmacologic target for autophagy regulation.Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis.
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Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 27 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
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Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
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type
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Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
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Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
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Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
@en
Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
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Metformin promotes autophagy a ...... ownregulating Stat3 signaling.
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S-C J Yeung
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10.1038/CDDIS.2014.59
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2014-02-27T00:00:00Z
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1016027290