Defining the conserved internal architecture of a protein kinase.
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Crystal structure of the Golgi casein kinaseNMR solution structure of human vaccinia-related kinase 1 (VRK1) reveals the C-terminal tail essential for its structural stability and autocatalytic activityThe role of the ALK receptor in cancer biologyImpact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilisDiscoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discoveryDynamics connect substrate recognition to catalysis in protein kinase AA new regulatory switch in a JAK protein kinaseStructural Basis for the Regulation of Protein Kinase A by Activation Loop PhosphorylationInhibitors that stabilize a closed RAF kinase domain conformation induce dimerizationSequence Determinants of a Specific Inactive Protein Kinase ConformationStructural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknBThe crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformationCrystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activityDiverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes.Mutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional SpecializationThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.Locking the active conformation of c-Src kinase through the phosphorylation of the activation loopStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding.A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life.Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA).A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinaseThe preclinical profile of crizotinib for the treatment of non-small-cell lung cancer and other neoplastic disorders.Allosteric communication across the native and mutated KIT receptor tyrosine kinase.Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy.Solution NMR insights into docking interactions involving inactive ERK2Computational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases.Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanismExpression and purification of Src-family kinases for solution NMR studies.Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to MembranesThe structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase.Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK.Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases.
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Defining the conserved internal architecture of a protein kinase.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Defining the conserved internal architecture of a protein kinase.
@en
Defining the conserved internal architecture of a protein kinase.
@nl
type
label
Defining the conserved internal architecture of a protein kinase.
@en
Defining the conserved internal architecture of a protein kinase.
@nl
prefLabel
Defining the conserved internal architecture of a protein kinase.
@en
Defining the conserved internal architecture of a protein kinase.
@nl
P2860
P1476
Defining the conserved internal architecture of a protein kinase
@en
P2093
Susan S Taylor
P2860
P304
P356
10.1016/J.BBAPAP.2009.10.017
P407
P577
2009-10-29T00:00:00Z