Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
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Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseCell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionDynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signalingTargeting cancer with kinase inhibitorsTo affinity and beyond: harnessing the T cell receptor for cancer immunotherapyCD28-CD80 interactions control regulatory T cell motility and immunological synapse formation.Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signalingActin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathwayCombinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.Protein networks and activation of lymphocytes.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Small molecule inhibition of Csk alters affinity recognition by T cells.LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.Insights into the initiation of TCR signaling.Confusing signals: recent progress in CTLA-4 biologyMolecular control of B cell activation and immunological synapse formation.Five Layers of Receptor Signaling in γδ T-Cell Differentiation and ActivationThe multifaceted role of PIP2 in leukocyte biology.CD28 Costimulation: From Mechanism to Therapy.Csk regulates angiotensin II-induced podocyte apoptosis.The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.Allele-sensitive mutant, Itkas, reveals that Itk kinase activity is required for Th1, Th2, Th17, and iNKT-cell cytokine production.TCR signaling: the barrier within.Dynamic regulation of CD28 conformation and signaling by charged lipids and ions.A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.Tonic Signals: Why Do Lymphocytes Bother?Maintenance of murine platelet homeostasis by the kinase Csk and the phosphatase CD148.Human c-SRC kinase (CSK) overexpression makes T cells dummy.Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation.The immunological synapse
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Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@en
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@nl
type
label
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@en
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@nl
prefLabel
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@en
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of the kinase Csk i ...... tiation of full TCR signaling.
@en
P2093
Boryana N Manz
Chao Zhang
Kevan M Shokat
Tanya S Freedman
Ying Xim Tan
P2860
P304
P356
10.1038/NI.2772
P407
P50
P577
2013-12-08T00:00:00Z