Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
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Chk1 suppressed cell deathCaspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loopCaspase-2 as a tumour suppressorThe PIDDosome, DNA-damage-induced apoptosis and beyondTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysStructural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and CatalysisOld, new and emerging functions of caspases.Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedSynergistic effects of apigenin and paclitaxel on apoptosis of cancer cellsA latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cellsCaspase-2-mediated cell death is required for deleting aneuploid cells.Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death.Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo.Hepatocyte death: a clear and present danger.Putative functions of caspase-2.Ocular neuroprotection by siRNA targeting caspase-2Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal.Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons.A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli.Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis.A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase 2 in primary human fibroblast cellsSponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina.Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.An unexpected role for caspase-2 in neuroblastoma.Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice.Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient miceCaspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8.PIDDosome-independent tumor suppression by Caspase-2.Age-related proteostasis and metabolic alterations in Caspase-2-deficient miceTRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells.Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates.Reduced BCL2 and CCND1 mRNA expression in human cervical cancer HeLa cells treated with a combination of everolimus and paclitaxel.Coenzyme Q10 rescues ethanol-induced corneal fibroblast apoptosis through the inhibition of caspase-2 activation.Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model.MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen.Caspase-2 and the oxidative stress response
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P2860
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
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2009年學術文章
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name
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@en
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@nl
type
label
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@en
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@nl
prefLabel
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@en
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@nl
P356
P1476
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
@en
P2860
P2888
P304
P356
10.1038/NRC2745
P407
P50
P577
2009-11-05T00:00:00Z