Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.
about
A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to RhoInteraction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signalingExpression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene productGAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunitsDirect control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomasActivation of Galphai3 triggers cell migration via regulation of GIV.Canonical and noncanonical g-protein signaling helps coordinate actin dynamics to promote macrophage phagocytosis of zymosanSDF1-induced antagonism of axonal repulsion requires multiple G-protein coupled signaling components that work in parallelAbnormalities in G protein-coupled signal transduction pathways in human disease.A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate.Regulation of hormone-sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells.Gi2-mediated activation of the MAP kinase cascade.Persistent membrane association of activated and depalmitoylated G protein alpha subunitsA Gsalpha mutant designed to inhibit receptor signaling through Gs.Integrins activate trimeric G proteins via the nonreceptor protein GIV/GirdinRegulation of receptor-coupling to (multiple) G proteins. A challenge for basic research and drug discovery.Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells.Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cellsThe small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cellsDominant negative mutants of transducin-alpha that block activated receptor.Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells.Gs alpha and Gi2 alpha mutations in clinically non-functioning pituitary tumours.A dominant-negative strategy for studying roles of G proteins in vivo.Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells.Activation of B-Raf and regulation of the mitogen-activated protein kinase pathway by the G(o) alpha chain.Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits.The G alpha subunit Gα8 inhibits proliferation, promotes adhesion and regulates cell differentiation.Trichoderma atroviride G-protein alpha-subunit gene tga1 is involved in mycoparasitic coiling and conidiation.Liddle syndrome: clinical and cellular abnormalities.G alpha COOH-terminal minigene vectors dissect heterotrimeric G protein signaling.Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype.Functional analysis of a dominant negative mutant of G alpha i2.The transforming activity of activated G alpha 12.Mutation of cysteine 214 in Gi1 alpha subunit abolishes its endogenous GTPase activity.Cell cycle and post-transcriptional regulation of annexin expression in IMR-90 human fibroblasts.Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma.
P2860
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P2860
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@en
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@nl
type
label
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@en
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@nl
prefLabel
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@en
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@nl
P2093
P2860
P356
P1476
Activating and inactivating mu ...... roliferation of NIH 3T3 cells.
@en
P2093
Gutkind JS
Hermouet S
Merendino JJ Jr
Spiegel AM
P2860
P304
10455-10459
P356
10.1073/PNAS.88.23.10455
P407
P577
1991-12-01T00:00:00Z