Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.
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Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathyPharmacological interventions for treating heart failure in patients with Chagas cardiomyopathyPharmacological interventions for treating heart failure in patients with Chagas cardiomyopathyIn vitro and in vivo trypanocidal activity of H2bdtc-loaded solid lipid nanoparticlesPharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from TipifarnibNon-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assayDesign, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseStructural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intrAntiparasitic therapyIn vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compoundsThe Trypanosoma cruzi protease cruzain mediates immune evasionDiverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineageTrypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell deathNatural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatidsA quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruziBenznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsMemantine, an antagonist of the NMDA glutamate receptor, affects cell proliferation, differentiation and the intracellular cycle and induces apoptosis in Trypanosoma cruziHepatotoxicity in mice of a novel anti-parasite drug candidate hydroxymethylnitrofurazone: a comparison with BenznidazoleBenznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas DiseaseValidation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruziSterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasisSesquiterpene lactone in nanostructured parenteral dosage form is efficacious in experimental Chagas disease.Ravuconazole self-emulsifying delivery system: in vitro activity against Trypanosoma cruzi amastigotes and in vivo toxicity.Methodological advances in drug discovery for Chagas disease.Parasitic loads in tissues of mice infected with Trypanosoma cruzi and treated with AmBisome.Short-term follow-up of chagasic patients after benzonidazole treatment using multiple serological markers.Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infectionProteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatidsNitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite deathAntileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine.Chagas disease and the london declaration on neglected tropical diseases.JVG9, a benzimidazole derivative, alters the surface and cytoskeleton of Trypanosoma cruzi bloodstream trypomastigotesDrug strategies targeting CYP51 in neglected tropical diseasesGenetic dissection of drug resistance in trypanosomesSynthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.Design and exploratory data analysis of a second generation of dendrimer prodrugs potentially antichagasic and leishmanicide.In vitro biological evaluation of eight different essential oils against Trypanosoma cruzi, with emphasis on Cinnamomum verum essential oil.The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA
P2860
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P2860
Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Specific chemotherapy of Chaga ...... imitations and new approaches.
@en
Specific chemotherapy of Chaga ...... imitations and new approaches.
@nl
type
label
Specific chemotherapy of Chaga ...... imitations and new approaches.
@en
Specific chemotherapy of Chaga ...... imitations and new approaches.
@nl
prefLabel
Specific chemotherapy of Chaga ...... imitations and new approaches.
@en
Specific chemotherapy of Chaga ...... imitations and new approaches.
@nl
P1433
P1476
Specific chemotherapy of Chaga ...... imitations and new approaches.
@en
P2093
Julio A Urbina
P356
10.1016/J.ACTATROPICA.2009.10.023
P5008
P577
2009-11-10T00:00:00Z