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Evidence that dynamin-2 functions as a signal-transducing GTPaseWip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent mannerHzf Determines cell survival upon genotoxic stress by modulating p53 transactivationMultivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damageTargeting Oncogenic Mutant p53 for Cancer TherapyInteraction of p53 with the CCT complex promotes protein folding and wild-type p53 activityIntegrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosisEffects of temperature on the p53-DNA binding interactions and their dynamical behavior: comparing the wild type to the R248Q mutant.HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.Hsp70 interactions with the p53 tumour suppressor protein.Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.Investigating DNA Binding and Conformational Variation in Temperature Sensitive p53 Cancer Mutants Using QM-MM Simulations.Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutantCancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population.Thermosensitive mutants of the MPTP and hPTP1B protein tyrosine phosphatases: isolation and structural analysis.p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKBp53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugsWild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression.Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells.Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.A direct effect of activated human p53 on nuclear DNA replication.Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53.DNA substrate dependence of p53-mediated regulation of double-strand break repair.Effects of stability on the biological function of p53.A proliferative p53-responsive element mediates tumor necrosis factor alpha induction of the human immunodeficiency virus type 1 long terminal repeatA mutant p53 that discriminates between p53-responsive genes cannot induce apoptosisTranscriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter.Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations.Temperature-sensitive ovarian carcinoma cell line (OvBH-1).Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factorsTemperature sensitivity for conformation is an intrinsic property of wild-type p53.Bax induction activates apoptotic cascade via mitochondrial cytochrome c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon cancer cells.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1994
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A temperature-sensitive mutant of human p53.
@en
A temperature-sensitive mutant of human p53.
@nl
type
label
A temperature-sensitive mutant of human p53.
@en
A temperature-sensitive mutant of human p53.
@nl
prefLabel
A temperature-sensitive mutant of human p53.
@en
A temperature-sensitive mutant of human p53.
@nl
P2093
P2860
P1433
P1476
A temperature-sensitive mutant of human p53
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1994.TB06543.X
P407
P577
1994-06-01T00:00:00Z