Genetic mechanisms and modifying factors in hereditary hemochromatosis.
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesDysregulation of iron and copper homeostasis in nonalcoholic fatty liverAccelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expressionComputational modeling and analysis of iron release from macrophages.Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis.Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosisIron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function.Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes.Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expressionElevated serum transaminase activities were associated with increased serum levels of iron regulatory hormone hepcidin and hyperferritinemia risk.Associations between Common Variants in Iron-Related Genes with Haematological Traits in Populations of African Ancestry.Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing.On myocardial siderosis and left ventricular dysfunction in hemochromatosis.Paraoxonase-1 status in patients with hereditary hemochromatosisWhere genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease.Disposal of iron by a mutant form of lipocalin 2.Iron Together with Lipid Downregulates Protein Levels of Ceruloplasmin in Macrophages Associated with Rapid Foam Cell Formation.Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study."Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levelsGenetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium InfectionHFE gene variants affect iron in the brain.Human iron transporters.Anaemia in inflammatory rheumatic diseases.Screening identifies the Chinese medicinal plant Caulis Spatholobi as an effective HAMP expression inhibitor.Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis.Facilitation of blood donation amongst haemochromatosis patients.Dietary iron loading negatively affects liver mitochondrial function.Glyceronephosphate O-acyltransferase as a hemochromatosis modifier gene: Another iron in the fire?Iron storage in liver, bone marrow and splenic Gaucheroma reflects residual disease in type 1 Gaucher disease patients on treatment.Worldwide policies on haemochromatosis and blood donation: a survey among blood services.Inadequate hepcidin serum concentrations predict incident type 2 diabetes mellitus.TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia
P2860
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P2860
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
@en
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
@nl
type
label
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
@en
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
@nl
prefLabel
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
@en
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
@nl
P2860
P1476
Genetic mechanisms and modifying factors in hereditary hemochromatosis
@en
P2093
Günter Weiss
P2860
P2888
P356
10.1038/NRGASTRO.2009.201
P407
P577
2009-11-17T00:00:00Z