Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution.
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Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase InhibitorsCrystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNAIdentification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagentFidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus.Structural prediction of A- and B-DNA duplexes based on coordinates of the phosphorus atomsReduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein.Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNAMutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.Antibody fragments as tools in crystallography.Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors.Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer.Trapping HIV-1 reverse transcriptase before and after translocation on DNA.Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptasesAsymmetric subunit organization of heterodimeric Rous sarcoma virus reverse transcriptase alphabeta: localization of the polymerase and RNase H active sites in the alpha subunit.RNase H requirements for the second strand transfer reaction of human immunodeficiency virus type 1 reverse transcription.Recent horizontal intron transfer to a chloroplast genome.Homodimeric reverse transcriptases from rous sarcoma virus mutated within the polymerase or RNase H active site of one subunit are active.Soluble Rous sarcoma virus reverse transcriptases alpha, alphabeta, and beta purified from insect cells are processive DNA polymerases that lack an RNase H 3' --> 5' directed processing activity.Use of a fusion protein to obtain crystals suitable for X-ray analysis: crystallization of a GST-fused protein containing the DNA-binding domain of DNA replication-related element-binding factor, DREFFamily A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors.The sequential mechanism of HIV reverse transcriptase RNase H.
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P2860
Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution.
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article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on December 1991
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@en
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@nl
type
label
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@en
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@nl
prefLabel
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@en
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@nl
P2093
P2860
P921
P356
P1476
Crystals of a ternary complex ...... ct x-rays to 3.5-A resolution.
@en
P2093
A Jacobo-Molina
A L Ferris
S H Hughes
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P304
10895-10899
P356
10.1073/PNAS.88.23.10895
P407
P577
1991-12-01T00:00:00Z