The sequential mechanism of HIV reverse transcriptase RNase H.
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RNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionCoordination between the polymerase and RNase H activity of HIV-1 reverse transcriptaseFactors that determine the efficiency of HIV-1 strand transfer initiated at a specific siteMechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genomeA succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transferDynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Duplex structural differences and not 2'-hydroxyls explain the more stable binding of HIV-reverse transcriptase to RNA-DNA versus DNA-DNA.Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.Human immunodeficiency virus type 2 reverse transcriptase activity in model systems that mimic steps in reverse transcription.Mechanisms and factors that influence high frequency retroviral recombinationPurine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis.Abolishing HIV-1 infectivity using a polypurine tract-specific G-quadruplex-forming oligonucleotideReverse transcriptase and integrase of the Saccharomyces cerevisiae Ty1 element.Tighter binding of HIV reverse transcriptase to RNA-DNA versus DNA-DNA results mostly from interactions in the polymerase domain and requires just a small stretch of RNA-DNA.Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein.Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.Efavirenz stimulates HIV-1 reverse transcriptase RNase H activity by a mechanism involving increased substrate binding and secondary cleavage activity.Host SAMHD1 protein promotes HIV-1 recombination in macrophages.Acceptor RNA cleavage profile supports an invasion mechanism for HIV-1 minus strand transfer.Biochemistry. RT slides home...The role of template-primer in protection of reverse transcriptase from thermal inactivation.Dissection of a circumscribed recombination hot spot in HIV-1 after a single infectious cycle.Altered strand transfer activity of a multiple-drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutant with a dipeptide fingers domain insertion.Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H.Extension and cleavage of the polypurine tract plus-strand primer by Ty1 reverse transcriptase.RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplexRNase H-mediated degradation of the template strandEvidence that HIV-1 reverse transcriptase employs the DNA 3' end-directed primary/secondary RNase H cleavage mechanism during synthesis and strand transfer.Interaction of HIV reverse transcriptase with structures mimicking recombination intermediates.
P2860
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P2860
The sequential mechanism of HIV reverse transcriptase RNase H.
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2000 nî lūn-bûn
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The sequential mechanism of HIV reverse transcriptase RNase H.
@en
The sequential mechanism of HIV reverse transcriptase RNase H.
@nl
type
label
The sequential mechanism of HIV reverse transcriptase RNase H.
@en
The sequential mechanism of HIV reverse transcriptase RNase H.
@nl
prefLabel
The sequential mechanism of HIV reverse transcriptase RNase H.
@en
The sequential mechanism of HIV reverse transcriptase RNase H.
@nl
P2093
P2860
P356
P1476
The sequential mechanism of HIV reverse transcriptase RNase H.
@en
P2093
Balakrishnan M
Bambara RA
Palaniappan C
Wisniewski M
P2860
P304
37664-37671
P356
10.1074/JBC.M007381200
P407
P577
2000-12-01T00:00:00Z