Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.
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The impact of human hyperekplexia mutations on glycine receptor structure and functionPrinciples of activation and permeation in an anion-selective Cys-loop receptorLigand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELICOpen-channel structures of the human glycine receptor α1 full-length transmembrane domain.X-ray structure of the human α4β2 nicotinic receptorAdvances and hold-ups in the study of structure, function and regulation of Cys-loop ligand-gated ion channels and receptorsFunctional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing groundβ2-Adrenergic ion-channel coupled receptors as conformational motion detectorsIn vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic toolAssessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology.A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.Mining the ChEMBL database: an efficient chemoinformatics workflow for assembling an ion channel-focused screening librarySpecificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiationAtomistic models of general anesthetics for use in in silico biological studiesInsights into a highly conserved network of hydrogen bonds in the agonist binding site of nicotinic acetylcholine receptors: a structural and theoretical study.Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel.Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspectiveDiscrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function.Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors.A microdeletion at Xq22.2 implicates a glycine receptor GLRA4 involved in intellectual disability, behavioral problems and craniofacial anomalies.Effects of lipid-analog detergent solubilization on the functionality and lipidic cubic phase mobility of the Torpedo californica nicotinic acetylcholine receptorDifferentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors.A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad in Frankliniella occidentalis.Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptorsAssessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor activation.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.The structural basis of function in Cys-loop receptors.Assembly of nicotinic and other Cys-loop receptors.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.The structural mechanism of the Cys-loop receptor desensitization.The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets.EPR Studies of Gating Mechanisms in Ion Channels.Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC).Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
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Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 December 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Atomic structure and dynamics ...... ght from bacterial homologues.
@en
Atomic structure and dynamics ...... ght from bacterial homologues.
@nl
type
label
Atomic structure and dynamics ...... ght from bacterial homologues.
@en
Atomic structure and dynamics ...... ght from bacterial homologues.
@nl
prefLabel
Atomic structure and dynamics ...... ght from bacterial homologues.
@en
Atomic structure and dynamics ...... ght from bacterial homologues.
@nl
P2093
P2860
P1476
Atomic structure and dynamics ...... ight from bacterial homologues
@en
P2093
Catherine Van Renterghem
Marc Delarue
Marie Prevost
Nicolas Bocquet
Pierre-Jean Corringer
Virginie Dufresne
P2860
P304
P356
10.1113/JPHYSIOL.2009.183160
P407
P577
2009-12-07T00:00:00Z