Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
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PDE4 inhibitors: current statusEfficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 InhibitorsFragment-Based Screening for Inhibitors of PDE4A Using Enthalpy Arrays and X-ray CrystallographyRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitorAdvances in targeting cyclic nucleotide phosphodiesterasesPhosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseEngineered stabilization and structural analysis of the autoinhibited conformation of PDE4Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsComparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous SystemTargeting cancer with phosphodiesterase inhibitors.Phosphodiesterase-4 inhibitors: a review of current developments (2010 - 2012).Phosphodiesterase-4 inhibition as a therapeutic strategy for metabolic disorders.Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.Electrostatic steering enhances the rate of cAMP binding to phosphodiesterase: Brownian dynamics modeling.Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors.PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts.The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss.The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.Assessing protein-ligand binding modes with computational tools: the case of PDE4B.Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.Discover natural compounds as potential phosphodiesterase-4B inhibitors via computational approaches.Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
P2860
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P2860
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors
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2007 nî lūn-bûn
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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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name
Structures of the four subfami ...... electivity of their inhibitors
@ast
Structures of the four subfami ...... electivity of their inhibitors
@en
Structures of the four subfami ...... electivity of their inhibitors
@nl
type
label
Structures of the four subfami ...... electivity of their inhibitors
@ast
Structures of the four subfami ...... electivity of their inhibitors
@en
Structures of the four subfami ...... electivity of their inhibitors
@nl
prefLabel
Structures of the four subfami ...... electivity of their inhibitors
@ast
Structures of the four subfami ...... electivity of their inhibitors
@en
Structures of the four subfami ...... electivity of their inhibitors
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structures of the four subfami ...... electivity of their inhibitors
@en
P2093
Howard Robinson
Huanchen Wang
Ming-Sheng Peng
P2860
P304
P3181
P356
10.1042/BJ20070970
P407
P577
2007-12-01T00:00:00Z